Matches in SemOpenAlex for { <https://semopenalex.org/work/W2619076717> ?p ?o ?g. }
- W2619076717 endingPage "1131" @default.
- W2619076717 startingPage "1131" @default.
- W2619076717 abstract "Hypertension (HTN) affects about 1 billion people worldwide and the lack of a single identifiable cause complicates its treatment. Blood pressure (BP) levels are influenced by environmental factors, but there is a strong genetic component. Linkage analysis has identified several genes involved in Mendelian forms of HTN and the associated pathophysiological mechanisms have been unravelled, leading to targeted therapies. The majority of these syndromes are due to gain-of-function or loss-of-functions mutations, resulting in an alteration of mineralocorticoid, glucocorticoid, or sympathetic pathways. The diagnosis of monogenic forms of HTN has limited practical implications on the population and a systematic genetic screening is not justifiable. Genome-wide linkage and association studies (GWAS) have identified single nucleotide polymorphisms (SNPs), which influence BP. Forty-three variants have been described with each SNP affecting systolic and diastolic BP by 1.0 and 0.5 mmHg, respectively. Taken together Mendelian inheritance and all GWAS-identified HTN-associated variants explain 2–3% of BP variance. Epigenetic modifications, such as DNA methylation, histone modification and non-coding RNAs, have become increasingly recognized as important players in BP regulation and may justify a further part of missing heritability. In this review, we will discuss how genetics and genomics may assist clinicians in managing patients with HTN." @default.
- W2619076717 created "2017-06-05" @default.
- W2619076717 creator A5012452729 @default.
- W2619076717 creator A5017595940 @default.
- W2619076717 creator A5023647519 @default.
- W2619076717 creator A5025351795 @default.
- W2619076717 creator A5027407695 @default.
- W2619076717 creator A5058757369 @default.
- W2619076717 creator A5068874880 @default.
- W2619076717 date "2017-05-26" @default.
- W2619076717 modified "2023-09-27" @default.
- W2619076717 title "Is There a Role for Genomics in the Management of Hypertension?" @default.
- W2619076717 cites W1496000386 @default.
- W2619076717 cites W1537435549 @default.
- W2619076717 cites W1603879262 @default.
- W2619076717 cites W1839250270 @default.
- W2619076717 cites W1905157184 @default.
- W2619076717 cites W1958109677 @default.
- W2619076717 cites W1967440935 @default.
- W2619076717 cites W1969194165 @default.
- W2619076717 cites W1978343601 @default.
- W2619076717 cites W1979069430 @default.
- W2619076717 cites W1982626564 @default.
- W2619076717 cites W1985396932 @default.
- W2619076717 cites W1986264879 @default.
- W2619076717 cites W1987918453 @default.
- W2619076717 cites W1987932410 @default.
- W2619076717 cites W1989630204 @default.
- W2619076717 cites W1989715435 @default.
- W2619076717 cites W1991102782 @default.
- W2619076717 cites W1996766484 @default.
- W2619076717 cites W1999448000 @default.
- W2619076717 cites W2000448320 @default.
- W2619076717 cites W2001944812 @default.
- W2619076717 cites W2008226844 @default.
- W2619076717 cites W2010461414 @default.
- W2619076717 cites W2012319132 @default.
- W2619076717 cites W2015183535 @default.
- W2619076717 cites W2021542491 @default.
- W2619076717 cites W2025886446 @default.
- W2619076717 cites W2035966105 @default.
- W2619076717 cites W2041469442 @default.
- W2619076717 cites W2042103448 @default.
- W2619076717 cites W2045591523 @default.
- W2619076717 cites W2046838656 @default.
- W2619076717 cites W2046926263 @default.
- W2619076717 cites W2047403541 @default.
- W2619076717 cites W2051712209 @default.
- W2619076717 cites W2052475265 @default.
- W2619076717 cites W2052724934 @default.
- W2619076717 cites W2061008984 @default.
- W2619076717 cites W2063800043 @default.
- W2619076717 cites W2073881942 @default.
- W2619076717 cites W2074551556 @default.
- W2619076717 cites W2075179216 @default.
- W2619076717 cites W2075199128 @default.
- W2619076717 cites W2077359836 @default.
- W2619076717 cites W2078764065 @default.
- W2619076717 cites W2088809097 @default.
- W2619076717 cites W2089400376 @default.
- W2619076717 cites W2094058624 @default.
- W2619076717 cites W2096444155 @default.
- W2619076717 cites W2099624608 @default.
- W2619076717 cites W2101605059 @default.
- W2619076717 cites W2102984318 @default.
- W2619076717 cites W2108790161 @default.
- W2619076717 cites W2110085945 @default.
- W2619076717 cites W2110343195 @default.
- W2619076717 cites W2111582520 @default.
- W2619076717 cites W2114901030 @default.
- W2619076717 cites W2115655044 @default.
- W2619076717 cites W2120347052 @default.
- W2619076717 cites W2120798274 @default.
- W2619076717 cites W2121923232 @default.
- W2619076717 cites W2124663880 @default.
- W2619076717 cites W2125170852 @default.
- W2619076717 cites W2134783591 @default.
- W2619076717 cites W2135281153 @default.
- W2619076717 cites W2136070934 @default.
- W2619076717 cites W2136078375 @default.
- W2619076717 cites W2140853270 @default.
- W2619076717 cites W2142766228 @default.
- W2619076717 cites W2143658931 @default.
- W2619076717 cites W2146864915 @default.
- W2619076717 cites W2149368867 @default.
- W2619076717 cites W2150717711 @default.
- W2619076717 cites W2154022245 @default.
- W2619076717 cites W2154308897 @default.
- W2619076717 cites W2154472871 @default.
- W2619076717 cites W2157165799 @default.
- W2619076717 cites W2157971623 @default.
- W2619076717 cites W2161555692 @default.
- W2619076717 cites W2161865054 @default.
- W2619076717 cites W2171234597 @default.
- W2619076717 cites W2171728648 @default.
- W2619076717 cites W2217809488 @default.
- W2619076717 cites W2266731778 @default.
- W2619076717 cites W2291498810 @default.