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- W2619194781 abstract "The aim of the present research work is to design and evaluate controlled release transdermal patches of selected cardiovascular drug losartan. Under with aim, the following major or broad objectives have been set to design and formulate matrix and membrane moderated based transdermal patch of losartan by solvent evaporation method using a few selected polymers as permeation enhancers such as HPMC, PVA, PVP, DMSO, DMF, Oleic acid, and Eudragit as release retardant for controlled release. To optimize the prepared formulations by different trial approaches. Losartan was chosen as a model drug for study since it possess near ideal characteristic that a drug must have in formulating a drug delivery system such as low molecular weight, high lipid solubility, effective in low plasma concentration as well as high degree of first-pass effect and short oral half-life of 1.5-2h has made the drug a suitable candidate for transdermal delivery. It also means multiple administrations with subsequent lack of patient compliance. The aim of the study was to prevent its first-pass metabolism and achieve control release by designing transdermal drug delivery system." @default.
- W2619194781 created "2017-06-05" @default.
- W2619194781 creator A5072890498 @default.
- W2619194781 date "2010-10-06" @default.
- W2619194781 modified "2023-09-23" @default.
- W2619194781 title "Design and evaluation of controlled release Transdermal dosage form of selected Cardiovascular drugs" @default.
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