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- W261919997 abstract "Publisher Summary This chapter describes the evidence for epithelium–capillary interactions where the two are apposed, emphasizing structural and functional manifestations such as capillary permeability and cell polarity. The observations derived from human ocular histopathology and experimental animal models are focused in which interactions are evident between (1) the retinal-pigment epithelium (RPE) and its apposed capillary plexus, the choriocapillaris and (2) RPE and retinal capillaries experimentally brought into apposition with RPE, from which they are normally isolated. These observations are relevant to the pathogenesis of chorioretinal diseases like age-related macular degeneration and retinitis pigmentosa. The biology of the RPE-choriocapillaris interactions determines the relative contributions of ECM components, soluble factors, and phenotypically different types of RPE cells to observations made in situ. They are the two causes of reduced vision and blindness that arise at the RPE and lead to complicating secondary changes in the adjacent choriocapillaris and neural retina. The possible mechanisms of RPE–choriocapillaris interactions are also discussed in the chapter." @default.
- W261919997 created "2016-06-24" @default.
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- W261919997 creator A5079465902 @default.
- W261919997 creator A5082239800 @default.
- W261919997 date "1989-01-01" @default.
- W261919997 modified "2023-10-14" @default.
- W261919997 title "Epithelium-Capillary Interactions in the Eye: The Retinal Pigment Epithelium and the Choriocapillaris" @default.
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- W261919997 doi "https://doi.org/10.1016/s0074-7696(08)60862-1" @default.
- W261919997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2661458" @default.
- W261919997 hasPublicationYear "1989" @default.
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