Matches in SemOpenAlex for { <https://semopenalex.org/work/W2619238970> ?p ?o ?g. }
- W2619238970 endingPage "917" @default.
- W2619238970 startingPage "911" @default.
- W2619238970 abstract "To assess the generation of reactive oxygen species (ROS) and the involvement of the main antioxidant pathways in low/intermediate-1-risk myelodysplastic syndromes (MDS) with iron overload (IOL).We examined the levels of superoxide anion (O2-), hydrogen peroxide (H2O2), antioxidants (glutathione, GSH; superoxide dismutase, SOD; catalase, CAT; and glutathione peroxidase, GPx), mitochondrial membrane potential (ΔΨm), and by-products of oxidative damage (8-isoprostanes and 8-oxo-7,8-dihydro-2'-deoxyguanosine, 8-oxo-dG) in 42 MDS patients (28 without IOL at diagnosis, and 14 who developed IOL) and 20 healthy subjects.Patients with IOL showed higher O2- levels (39.4 MFI) than normal controls (22.7 MFI, p=0.0356) and patients at diagnosis (19.4 MFI, p=0.0049). Antioxidant systems, except SOD activity, exhibited significant changes in IOL patients with respect to controls (CAT: 7.1 vs 2.7nmol/ml/min, p=0.0023; GPx: 50.9 vs 76.4nmol/ml/min, p=0.0291; GSH: 50.2 vs 24.1 MFI, p=0.0060). Furthermore, mitochondrial dysfunction was only detected in IOL cases compared to controls (ΔΨm: 3.6 vs 6.4 MFI, p=0.0225). Finally, increased levels of 8-oxo-dG were detected in both groups of patients.Oxidative stress is an important but non-static phenomenon in MDS disease, whose status is influenced by, among other factors, the presence of injurious iron." @default.
- W2619238970 created "2017-06-05" @default.
- W2619238970 creator A5000206245 @default.
- W2619238970 creator A5010010012 @default.
- W2619238970 creator A5015986995 @default.
- W2619238970 creator A5017669978 @default.
- W2619238970 creator A5017703525 @default.
- W2619238970 creator A5020327336 @default.
- W2619238970 creator A5022466989 @default.
- W2619238970 creator A5031173832 @default.
- W2619238970 creator A5031925280 @default.
- W2619238970 creator A5032820788 @default.
- W2619238970 creator A5043823692 @default.
- W2619238970 creator A5053498360 @default.
- W2619238970 creator A5055662908 @default.
- W2619238970 creator A5063590670 @default.
- W2619238970 creator A5068503915 @default.
- W2619238970 creator A5068745310 @default.
- W2619238970 creator A5072382813 @default.
- W2619238970 creator A5075631564 @default.
- W2619238970 creator A5084819300 @default.
- W2619238970 creator A5091736381 @default.
- W2619238970 date "2017-11-01" @default.
- W2619238970 modified "2023-10-16" @default.
- W2619238970 title "Oxidative imbalance in low/intermediate-1-risk myelodysplastic syndrome patients: The influence of iron overload" @default.
- W2619238970 cites W1500296017 @default.
- W2619238970 cites W1546482094 @default.
- W2619238970 cites W187238933 @default.
- W2619238970 cites W1969935717 @default.
- W2619238970 cites W1983658905 @default.
- W2619238970 cites W1992668261 @default.
- W2619238970 cites W1997183854 @default.
- W2619238970 cites W2002794485 @default.
- W2619238970 cites W2008297010 @default.
- W2619238970 cites W2020046064 @default.
- W2619238970 cites W2020511303 @default.
- W2619238970 cites W2038144895 @default.
- W2619238970 cites W2041724441 @default.
- W2619238970 cites W2042000209 @default.
- W2619238970 cites W2052822682 @default.
- W2619238970 cites W2056149198 @default.
- W2619238970 cites W2059413634 @default.
- W2619238970 cites W2065476145 @default.
- W2619238970 cites W2065796693 @default.
- W2619238970 cites W2071128441 @default.
- W2619238970 cites W2071488331 @default.
- W2619238970 cites W2076387297 @default.
- W2619238970 cites W2078904403 @default.
- W2619238970 cites W2084734336 @default.
- W2619238970 cites W2096621682 @default.
- W2619238970 cites W2108489423 @default.
- W2619238970 cites W2114634924 @default.
- W2619238970 cites W2126618177 @default.
- W2619238970 cites W2141088965 @default.
- W2619238970 cites W2142321393 @default.
- W2619238970 cites W2142408803 @default.
- W2619238970 cites W2143956045 @default.
- W2619238970 cites W2148225570 @default.
- W2619238970 cites W2166892083 @default.
- W2619238970 cites W2172277198 @default.
- W2619238970 cites W2188751783 @default.
- W2619238970 cites W312432398 @default.
- W2619238970 doi "https://doi.org/10.1016/j.clinbiochem.2017.05.018" @default.
- W2619238970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28571970" @default.
- W2619238970 hasPublicationYear "2017" @default.
- W2619238970 type Work @default.
- W2619238970 sameAs 2619238970 @default.
- W2619238970 citedByCount "17" @default.
- W2619238970 countsByYear W26192389702018 @default.
- W2619238970 countsByYear W26192389702019 @default.
- W2619238970 countsByYear W26192389702020 @default.
- W2619238970 countsByYear W26192389702021 @default.
- W2619238970 countsByYear W26192389702022 @default.
- W2619238970 countsByYear W26192389702023 @default.
- W2619238970 crossrefType "journal-article" @default.
- W2619238970 hasAuthorship W2619238970A5000206245 @default.
- W2619238970 hasAuthorship W2619238970A5010010012 @default.
- W2619238970 hasAuthorship W2619238970A5015986995 @default.
- W2619238970 hasAuthorship W2619238970A5017669978 @default.
- W2619238970 hasAuthorship W2619238970A5017703525 @default.
- W2619238970 hasAuthorship W2619238970A5020327336 @default.
- W2619238970 hasAuthorship W2619238970A5022466989 @default.
- W2619238970 hasAuthorship W2619238970A5031173832 @default.
- W2619238970 hasAuthorship W2619238970A5031925280 @default.
- W2619238970 hasAuthorship W2619238970A5032820788 @default.
- W2619238970 hasAuthorship W2619238970A5043823692 @default.
- W2619238970 hasAuthorship W2619238970A5053498360 @default.
- W2619238970 hasAuthorship W2619238970A5055662908 @default.
- W2619238970 hasAuthorship W2619238970A5063590670 @default.
- W2619238970 hasAuthorship W2619238970A5068503915 @default.
- W2619238970 hasAuthorship W2619238970A5068745310 @default.
- W2619238970 hasAuthorship W2619238970A5072382813 @default.
- W2619238970 hasAuthorship W2619238970A5075631564 @default.
- W2619238970 hasAuthorship W2619238970A5084819300 @default.
- W2619238970 hasAuthorship W2619238970A5091736381 @default.
- W2619238970 hasConcept C126322002 @default.
- W2619238970 hasConcept C134018914 @default.
- W2619238970 hasConcept C181199279 @default.