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- W2619285731 abstract "Abstract Toxic leukoencephalopathy (TLE) is a rare sequel of cocaine abuse with a reported mortality around 23%. It can be associated with any method of drug delivery. It is possible that the number of adulterants as well as the pureness of the substance may play a role. Levamisole is one of the most common adulterants of cocaine and is associated with the occurrence of LE. The diagnosis requires that the clinician have a high index of suspicion with documented exposure to cocaine, neurobehavioral deficits, and neuroradiological abnormalities. TL does not affect the cortex, language is preserved, and motor, sensory, or visual deficits are rare. Brain MR shows diffuse, symmetrical white matter hyperintensities on T2 and fluid-attenuated inversion recover sequences. The clinical spectrum of TL generally parallels the severity of white-matter damage as well as its distribution. Treatment remains primarily supportive." @default.
- W2619285731 created "2017-06-05" @default.
- W2619285731 creator A5081059143 @default.
- W2619285731 date "2017-01-01" @default.
- W2619285731 modified "2023-09-24" @default.
- W2619285731 title "Leukoencephalopathy and the Use of Cocaine" @default.
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- W2619285731 doi "https://doi.org/10.1016/b978-0-12-803750-8.00031-2" @default.
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