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- W2619377514 abstract "(Cell 139, 312–324; October 16, 2009) An incorrect accession number was listed in the print and original online versions of this article. The correct Protein Data Bank accession numbers are 3IKL and 3IKM. The online version of this article has been corrected. Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase MutationsLee et al.CellOctober 16, 2009In BriefHuman mitochondrial DNA polymerase (Pol γ) is the sole replicase in mitochondria. Pol γ is vulnerable to nonselective antiretroviral drugs and is increasingly associated with mutations found in patients with mitochondriopathies. We determined crystal structures of the human heterotrimeric Pol γ holoenzyme and, separately, a variant of its processivity factor, Pol γB. The holoenzyme structure reveals an unexpected assembly of the mitochondrial DNA replicase where the catalytic subunit Pol γA interacts with its processivity factor primarily via a domain that is absent in all other DNA polymerases. Full-Text PDF Open Archive" @default.
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- W2619377514 date "2009-11-01" @default.
- W2619377514 modified "2023-09-28" @default.
- W2619377514 title "Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase Mutations" @default.
- W2619377514 doi "https://doi.org/10.1016/j.cell.2009.10.026" @default.
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