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• W2619457553 abstract "Spontaneous physical activity (SPA) comprehends all daily physical activities other than volitional exercise (e.g. sports-related activities). The energy spent in SPA can represent up to 50% of the total daily energy expenditure. Little is known regarding the biological regulation of SPA, especially during ageing, when SPA is known to decline. As a mediator of energy homeostasis, hypothalamic leptin signaling may be involved. PURPOSE: to investigate the temporal relationship between hypothalamic leptin signaling and SPA in mice from 4 to 10 months of age. METHODS: Male C57bl/6 mice were divided into three groups, according to age: 4 (4M, n=10), 6 (6M, n=10) and 10 (10M, n=20) months-old mice. SPA, distance travelled (DT), average speed of locomotion (AS) and energy expenditure (EE) were measured monthly from 4 to 10 months of age in the 10M group. Hypothalamic expression of STAT3 and phosphorylated STAT3 (pSTAT3) by Western Blotting, intraperitoneal glucose tolerance test (ipGTT), and retroperitoneal (RAT) and epidydimal (EAT) adipose tissue weight were determined in all the groups (4M, 6M and 10M). Results are shown as mean + standard error of the mean. Repeated measures ANOVA or One-way ANOVA were employed and the Newman-Keuls post hoc test was used when necessary. Significance was set at p<0.05. RESULTS: Compared to the 4th month, SPA, DT and AS started to decrease in the 6th month (p<0.05) and persisted reduced all over (SPA 30%; DT 25%; AS 25% decrease in the 10th month). EE decreased (p<0.05) in the last three months (19% decrease in the 10th month). Hypothalamic pSTAT3 decreased (p<0.05) in 6M and 10M in relation to 4M (4M: 0.83 + 0.28; 6M: 0.52 + 0.16*; 10M: 0.53 + 0.17* arbitrary units). STAT3 decreased 45% in 10M compared with 6M, but it was not statistically significant (p=0.09). The area under the curve of ipGTT (4M: 31,228 + 9,875; 6M: 36,776* + 11,629 10M: 40,544* + 13,514 mg/dL x 120 minutes), and the weight of RAT (4M: 3.76 + 1.19; 6M: 9.58* + 3.03; 10M: 9.76* + 3.25 mg/g) and EAT (4M: 14.59 + 4.61; 6M: 29.28* + 9.26; 10M: 26.87* + 8.96 mg/g) increased (p<0.05) in 6M and 10M groups when compared to 4M group. CONCLUSIONS: Decreases in SPA, DT and AS were accompanied by a reduction of hypothalamic leptin signaling. Besides, glucose intolerance and increased fat pads weight manifested when SPA declined. Supported by: FAPESP and CAPES." @default.
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• W2619457553 date "2017-05-01" @default.
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• W2619457553 title "Hypothalamic Leptin Signaling Modulates Spontaneous Physical Activity During Ageing in Mice." @default.
• W2619457553 doi "https://doi.org/10.1249/01.mss.0000518864.00468.66" @default.
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