Matches in SemOpenAlex for { <https://semopenalex.org/work/W2619593032> ?p ?o ?g. }
- W2619593032 abstract "The immune response is a key factor in the fight against HPV infection and related cancers, and thus, HPV is able to promote immune evasion through the expression of oncogenes. In particular, the E5 oncogene is responsible for modulation of several immune mechanisms, including antigen presentation and inflammatory pathways. Moreover, E5 was suggested as a promising therapeutic target, since there is still no effective medical therapy for the treatment of HPV-related pre-neoplasia and cancer. Indeed, several studies have shown good prospective for E5 immunotherapy, suggesting that it could be applied for the treatment of pre-cancerous lesions. Thus, insofar as the majority of cervical, oropharyngeal and anal cancers are caused by high-risk HPV (hrHPV), mainly by HPV16, the aim of this review is to discuss the immune pathways interfered by E5 oncoprotein of hrHPV highlighting the various aspects of the potential immunotherapeutic approaches." @default.
- W2619593032 created "2017-06-05" @default.
- W2619593032 creator A5010355570 @default.
- W2619593032 creator A5067108303 @default.
- W2619593032 creator A5069565345 @default.
- W2619593032 creator A5084435760 @default.
- W2619593032 date "2017-05-25" @default.
- W2619593032 modified "2023-10-16" @default.
- W2619593032 title "hrHPV E5 oncoprotein: immune evasion and related immunotherapies" @default.
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