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• W2619601597 endingPage "119" @default.
• W2619601597 startingPage "103" @default.
• W2619601597 abstract "BDE-209, a congener of polybrominated diphenyl ethers (PBDEs), is mainly used as flame retardant and accounts for over 82% of total PBDE usage. PBDEs have recently been detected in human milk and cord blood. BDE-209 possesses weak estrogenic/anti-estrogenic properties and evokes hyperglycemia through impaired glucose homeostasis in rat liver. However, little is known of the effect of lactational exposure to BDE-209 on germ cell survival in relation to testicular glucose homeostasis, estradiol and oxidative status during prepubertal period. The present study, therefore, evaluated the effect of maternal exposure to BDE-209 during lactation on above-mentioned parameters with reference to Cx43 and p27Kip1 in prepubertal Parkes (P) mice offspring. Lactating female P mice were orally gavaged with 500, and 700 mg/kg body weight of BDE-209 in corn oil from postnatal day (PND) 0 to PND 28; male pups were euthanized at PND 21 and 28. Maternal exposure to BDE-209 during lactation increased germ cell apoptosis with altered expressions of various cell survival and apoptotic markers along with decreased expression of Cx43 and p27Kip1 in prepubertal mice offspring. Testicular glucose and lactate concentrations were markedly reduced in these pups with down-regulation in GLUT3 and GLUT8 expressions and decreased LDH activity. Rise in oxidative stress in testes with increased estrogen level in these pups was also noted. In conclusion, our results suggest that maternal BDE-209 exposure during lactation affects germ cell survival with altered testicular glucose homeostasis and oxidative status through down-regulation of Cx43 and p27Kip1 in prepubertal mice offspring." @default.
• W2619601597 created "2017-06-05" @default.
• W2619601597 creator A5031673933 @default.
• W2619601597 creator A5065498407 @default.
• W2619601597 date "2017-07-01" @default.
• W2619601597 modified "2023-09-30" @default.
• W2619601597 title "Maternal exposure to polybrominated diphenyl ether (BDE-209) during lactation affects germ cell survival with altered testicular glucose homeostasis and oxidative status through down-regulation of Cx43 and p27Kip1 in prepubertal mice offspring" @default.
• W2619601597 cites W1449229609 @default.
• W2619601597 cites W1511003303 @default.
• W2619601597 cites W1775749144 @default.
• W2619601597 cites W1801385241 @default.
• W2619601597 cites W1844503037 @default.
• W2619601597 cites W1967621091 @default.
• W2619601597 cites W1969658536 @default.
• W2619601597 cites W1970874830 @default.
• W2619601597 cites W1971425761 @default.
• W2619601597 cites W1972464403 @default.
• W2619601597 cites W1977337002 @default.
• W2619601597 cites W1980550534 @default.
• W2619601597 cites W1980644097 @default.
• W2619601597 cites W1981264454 @default.
• W2619601597 cites W1981379726 @default.
• W2619601597 cites W1983002136 @default.
• W2619601597 cites W1983310681 @default.
• W2619601597 cites W1984877419 @default.
• W2619601597 cites W1987338052 @default.
• W2619601597 cites W1989634621 @default.
• W2619601597 cites W1992639634 @default.
• W2619601597 cites W2003270319 @default.
• W2619601597 cites W2004473724 @default.
• W2619601597 cites W2012339354 @default.
• W2619601597 cites W2013613091 @default.
• W2619601597 cites W2017399463 @default.
• W2619601597 cites W2021451870 @default.
• W2619601597 cites W2025175568 @default.
• W2619601597 cites W2029713907 @default.
• W2619601597 cites W2029867191 @default.
• W2619601597 cites W2031754021 @default.
• W2619601597 cites W2042647949 @default.
• W2619601597 cites W2045717371 @default.
• W2619601597 cites W2046011724 @default.
• W2619601597 cites W2053130514 @default.
• W2619601597 cites W2054162052 @default.
• W2619601597 cites W2056435013 @default.
• W2619601597 cites W2057358681 @default.
• W2619601597 cites W2057881071 @default.
• W2619601597 cites W2059206875 @default.
• W2619601597 cites W2060950196 @default.
• W2619601597 cites W2063375403 @default.
• W2619601597 cites W2063807196 @default.
• W2619601597 cites W2064380996 @default.
• W2619601597 cites W2067146341 @default.
• W2619601597 cites W2067768224 @default.
• W2619601597 cites W2072094999 @default.
• W2619601597 cites W2073572747 @default.
• W2619601597 cites W2073594804 @default.
• W2619601597 cites W2075883978 @default.
• W2619601597 cites W2078804787 @default.
• W2619601597 cites W2079712252 @default.
• W2619601597 cites W2079988480 @default.
• W2619601597 cites W2083561654 @default.
• W2619601597 cites W2085920093 @default.
• W2619601597 cites W2087504896 @default.
• W2619601597 cites W2088298040 @default.
• W2619601597 cites W2090053315 @default.
• W2619601597 cites W2091422078 @default.
• W2619601597 cites W2092136005 @default.
• W2619601597 cites W2094891571 @default.
• W2619601597 cites W2095171297 @default.
• W2619601597 cites W2095907411 @default.
• W2619601597 cites W2101322950 @default.
• W2619601597 cites W2106666165 @default.
• W2619601597 cites W2107665811 @default.
• W2619601597 cites W2109561093 @default.
• W2619601597 cites W2132024398 @default.
• W2619601597 cites W2132809876 @default.
• W2619601597 cites W2137157799 @default.
• W2619601597 cites W2138611802 @default.
• W2619601597 cites W2138982344 @default.
• W2619601597 cites W2148211341 @default.
• W2619601597 cites W2150348717 @default.
• W2619601597 cites W2150970097 @default.
• W2619601597 cites W2154903663 @default.
• W2619601597 cites W2155658630 @default.
• W2619601597 cites W2158256060 @default.
• W2619601597 cites W2165259501 @default.
• W2619601597 cites W2218772004 @default.
• W2619601597 cites W2231114050 @default.
• W2619601597 cites W2293237391 @default.
• W2619601597 cites W2345541432 @default.
• W2619601597 cites W2410772376 @default.
• W2619601597 cites W2423506215 @default.
• W2619601597 cites W2469425187 @default.
• W2619601597 cites W2510062958 @default.
• W2619601597 cites W2521931817 @default.
• W2619601597 cites W2559751763 @default.
• W2619601597 doi "https://doi.org/10.1016/j.tox.2017.05.016" @default.
• W2619601597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28572024" @default.

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