FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2619679515> ?p ?o ?g. }

• W2619679515 abstract "Abstract Excessive alcohol consumption is a known risk factor for stroke, but the effect of stroke on alcohol intake is unknown. The dorsomedial striatum (DMS) and midbrain areas of the nigrostriatal circuit are critically associated to stroke and alcohol addiction. Here we sought to explore the influence of stroke on alcohol consumption and to uncover the underlying nigrostriatal mechanism. Rats were trained to consume alcohol using a two-bottle choice or operant self-administration procedure. Retrograde beads were infused into the DMS or midbrain to label specific neuronal types, and ischemic stroke was induced in the dorsolateral striatum (DLS). Slice electrophysiology was employed to measure excitability and synaptic transmission in DMS and midbrain neurons. We found that ischemic stroke-induced DLS infarction produced significant increases in alcohol preference, operant self-administration, and relapse. These increases were accompanied by enhanced excitability of DMS and midbrain neurons. In addition, glutamatergic inputs onto DMS D1-neurons was potentiated, whereas GABAergic inputs onto DMS-projecting midbrain dopaminergic neurons was suppressed. Importantly, systemic inhibition of dopamine D1 receptors attenuated the stroke-induced increase in operant alcohol self-administration. Our results suggest that the stroke-induced DLS infarction evoked abnormal plasticity in nigrostriatal dopaminergic neurons and DMS D1-neurons, contributing to increased post-stroke alcohol-seeking and relapse." @default.
• W2619679515 created "2017-06-05" @default.
• W2619679515 creator A5015696159 @default.
• W2619679515 creator A5027118370 @default.
• W2619679515 creator A5035271950 @default.
• W2619679515 creator A5042241049 @default.
• W2619679515 creator A5066859836 @default.
• W2619679515 creator A5073433254 @default.
• W2619679515 creator A5082358939 @default.
• W2619679515 creator A5088685757 @default.
• W2619679515 date "2017-05-31" @default.
• W2619679515 modified "2023-10-05" @default.
• W2619679515 title "Stroke triggers nigrostriatal plasticity and increases alcohol consumption in rats" @default.
• W2619679515 cites W1506803949 @default.
• W2619679515 cites W1568910178 @default.
• W2619679515 cites W1632482896 @default.
• W2619679515 cites W1664214798 @default.
• W2619679515 cites W1875506666 @default.
• W2619679515 cites W1966343623 @default.
• W2619679515 cites W1973788414 @default.
• W2619679515 cites W1978029612 @default.
• W2619679515 cites W1978625035 @default.
• W2619679515 cites W1979907771 @default.
• W2619679515 cites W1985396944 @default.
• W2619679515 cites W1986420920 @default.
• W2619679515 cites W1991494792 @default.
• W2619679515 cites W1991726278 @default.
• W2619679515 cites W1994669704 @default.
• W2619679515 cites W2000526220 @default.
• W2619679515 cites W2008762508 @default.
• W2619679515 cites W2011293417 @default.
• W2619679515 cites W2014035493 @default.
• W2619679515 cites W2022035248 @default.
• W2619679515 cites W2029725565 @default.
• W2619679515 cites W2029725727 @default.
• W2619679515 cites W2036768211 @default.
• W2619679515 cites W2039502763 @default.
• W2619679515 cites W2041937221 @default.
• W2619679515 cites W2045421141 @default.
• W2619679515 cites W2045642258 @default.
• W2619679515 cites W2047790410 @default.
• W2619679515 cites W2050061925 @default.
• W2619679515 cites W2051239559 @default.
• W2619679515 cites W2063541896 @default.
• W2619679515 cites W2063893203 @default.
• W2619679515 cites W2066441222 @default.
• W2619679515 cites W2068076865 @default.
• W2619679515 cites W2068401524 @default.
• W2619679515 cites W2069533687 @default.
• W2619679515 cites W2079590230 @default.
• W2619679515 cites W2088134302 @default.
• W2619679515 cites W2105726924 @default.
• W2619679515 cites W2110925924 @default.
• W2619679515 cites W2118830830 @default.
• W2619679515 cites W2129542892 @default.
• W2619679515 cites W2135159454 @default.
• W2619679515 cites W2138419643 @default.
• W2619679515 cites W2141604604 @default.
• W2619679515 cites W2153998371 @default.
• W2619679515 cites W2201272991 @default.
• W2619679515 cites W2396428346 @default.
• W2619679515 cites W2915502572 @default.
• W2619679515 doi "https://doi.org/10.1038/s41598-017-02714-z" @default.
• W2619679515 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5451385" @default.
• W2619679515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28566754" @default.
• W2619679515 hasPublicationYear "2017" @default.
• W2619679515 type Work @default.
• W2619679515 sameAs 2619679515 @default.
• W2619679515 citedByCount "19" @default.
• W2619679515 countsByYear W26196795152018 @default.
• W2619679515 countsByYear W26196795152019 @default.
• W2619679515 countsByYear W26196795152020 @default.
• W2619679515 countsByYear W26196795152021 @default.
• W2619679515 countsByYear W26196795152022 @default.
• W2619679515 countsByYear W26196795152023 @default.
• W2619679515 crossrefType "journal-article" @default.
• W2619679515 hasAuthorship W2619679515A5015696159 @default.
• W2619679515 hasAuthorship W2619679515A5027118370 @default.
• W2619679515 hasAuthorship W2619679515A5035271950 @default.
• W2619679515 hasAuthorship W2619679515A5042241049 @default.
• W2619679515 hasAuthorship W2619679515A5066859836 @default.
• W2619679515 hasAuthorship W2619679515A5073433254 @default.
• W2619679515 hasAuthorship W2619679515A5082358939 @default.
• W2619679515 hasAuthorship W2619679515A5088685757 @default.
• W2619679515 hasBestOaLocation W26196795151 @default.
• W2619679515 hasConcept C127413603 @default.
• W2619679515 hasConcept C137183658 @default.
• W2619679515 hasConcept C15744967 @default.
• W2619679515 hasConcept C169760540 @default.
• W2619679515 hasConcept C2776355744 @default.
• W2619679515 hasConcept C2780062018 @default.
• W2619679515 hasConcept C2780645631 @default.
• W2619679515 hasConcept C2780938664 @default.
• W2619679515 hasConcept C48856860 @default.
• W2619679515 hasConcept C513476851 @default.
• W2619679515 hasConcept C529278444 @default.
• W2619679515 hasConcept C552161191 @default.
• W2619679515 hasConcept C71924100 @default.
• W2619679515 hasConcept C78519656 @default.
• W2619679515 hasConceptScore W2619679515C127413603 @default.

• next