Matches in SemOpenAlex for { <https://semopenalex.org/work/W2619681384> ?p ?o ?g. }
- W2619681384 endingPage "435" @default.
- W2619681384 startingPage "430" @default.
- W2619681384 abstract "Background: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease. For controlling the disease activity, various therapeutic modalities are used. Each of them have advantages and limitations. This study analyzes effectiveness and toxicity of methotrexate (MTX) on liver and lipid functions in selected RA patients and controls. Methods: This study included samples of patients with RA who were on MTX therapy and had long-term follow-up. The control and patient samples were used for analysis of lipid parameters, inflammatory markers as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), essential mineral accumulation, and liver and kidney function test. Results: Hemoglobin was reduced in RA patients; however, ESR, CRP and pain on the visual analog scale were significantly higher as compared to controls. Their alanine aminotransferase, aspartate aminotransferase and uric acid were within normal ranges. Serum magnesium was significantly reduced in RA patients. They showed higher values for zinc, phosphorous, and copper. They had borderline dyslipidemia. Conclusions: MTX was found to be safe and effective for treatment of RA. The liver function test of RA patients was normal. They had disturbances in mineral accumulation, suggesting the requirement of mineral evaluation and supplementation especially of magnesium in RA patients. The treatment was beneficial in reducing inflammation and reducing the activity of the disease. The treatment was also beneficial for lipid parameters reducing the risk of cardiovascular disease. The study supports MTX as the good choice for treatment of RA." @default.
- W2619681384 created "2017-06-05" @default.
- W2619681384 creator A5002759235 @default.
- W2619681384 creator A5021420976 @default.
- W2619681384 creator A5023004530 @default.
- W2619681384 creator A5026266434 @default.
- W2619681384 creator A5033198954 @default.
- W2619681384 creator A5061061658 @default.
- W2619681384 date "2017-07-01" @default.
- W2619681384 modified "2023-09-25" @default.
- W2619681384 title "Methotrexate as effective and safe choice for the treatment of rheumatoid arthritis" @default.
- W2619681384 cites W1597643670 @default.
- W2619681384 cites W1979473337 @default.
- W2619681384 cites W1997282832 @default.
- W2619681384 cites W2002959856 @default.
- W2619681384 cites W2008004594 @default.
- W2619681384 cites W2016172564 @default.
- W2619681384 cites W2017266205 @default.
- W2619681384 cites W2022544920 @default.
- W2619681384 cites W2027271958 @default.
- W2619681384 cites W2028247096 @default.
- W2619681384 cites W2028912994 @default.
- W2619681384 cites W2033508685 @default.
- W2619681384 cites W2053153138 @default.
- W2619681384 cites W2057392381 @default.
- W2619681384 cites W2058006546 @default.
- W2619681384 cites W2077836946 @default.
- W2619681384 cites W2081636621 @default.
- W2619681384 cites W2096818146 @default.
- W2619681384 cites W2105298192 @default.
- W2619681384 cites W2107364634 @default.
- W2619681384 cites W2110576380 @default.
- W2619681384 cites W2113679049 @default.
- W2619681384 cites W2120574509 @default.
- W2619681384 cites W2120700478 @default.
- W2619681384 cites W2123037988 @default.
- W2619681384 cites W2142315141 @default.
- W2619681384 cites W2145635335 @default.
- W2619681384 cites W2149899765 @default.
- W2619681384 cites W2151279508 @default.
- W2619681384 cites W2152348310 @default.
- W2619681384 cites W2153297648 @default.
- W2619681384 cites W2153924104 @default.
- W2619681384 cites W2315575691 @default.
- W2619681384 cites W2329686867 @default.
- W2619681384 cites W2336588424 @default.
- W2619681384 cites W2509771898 @default.
- W2619681384 cites W3006080604 @default.
- W2619681384 cites W4210968471 @default.
- W2619681384 doi "https://doi.org/10.1097/bco.0000000000000517" @default.
- W2619681384 hasPublicationYear "2017" @default.
- W2619681384 type Work @default.
- W2619681384 sameAs 2619681384 @default.
- W2619681384 citedByCount "1" @default.
- W2619681384 countsByYear W26196813842022 @default.
- W2619681384 crossrefType "journal-article" @default.
- W2619681384 hasAuthorship W2619681384A5002759235 @default.
- W2619681384 hasAuthorship W2619681384A5021420976 @default.
- W2619681384 hasAuthorship W2619681384A5023004530 @default.
- W2619681384 hasAuthorship W2619681384A5026266434 @default.
- W2619681384 hasAuthorship W2619681384A5033198954 @default.
- W2619681384 hasAuthorship W2619681384A5061061658 @default.
- W2619681384 hasConcept C126322002 @default.
- W2619681384 hasConcept C2777575956 @default.
- W2619681384 hasConcept C2778096610 @default.
- W2619681384 hasConcept C2778143017 @default.
- W2619681384 hasConcept C2778163477 @default.
- W2619681384 hasConcept C2778270857 @default.
- W2619681384 hasConcept C2779134260 @default.
- W2619681384 hasConcept C2779881121 @default.
- W2619681384 hasConcept C2781059491 @default.
- W2619681384 hasConcept C2992208098 @default.
- W2619681384 hasConcept C512861765 @default.
- W2619681384 hasConcept C71924100 @default.
- W2619681384 hasConcept C90924648 @default.
- W2619681384 hasConceptScore W2619681384C126322002 @default.
- W2619681384 hasConceptScore W2619681384C2777575956 @default.
- W2619681384 hasConceptScore W2619681384C2778096610 @default.
- W2619681384 hasConceptScore W2619681384C2778143017 @default.
- W2619681384 hasConceptScore W2619681384C2778163477 @default.
- W2619681384 hasConceptScore W2619681384C2778270857 @default.
- W2619681384 hasConceptScore W2619681384C2779134260 @default.
- W2619681384 hasConceptScore W2619681384C2779881121 @default.
- W2619681384 hasConceptScore W2619681384C2781059491 @default.
- W2619681384 hasConceptScore W2619681384C2992208098 @default.
- W2619681384 hasConceptScore W2619681384C512861765 @default.
- W2619681384 hasConceptScore W2619681384C71924100 @default.
- W2619681384 hasConceptScore W2619681384C90924648 @default.
- W2619681384 hasIssue "4" @default.
- W2619681384 hasLocation W26196813841 @default.
- W2619681384 hasOpenAccess W2619681384 @default.
- W2619681384 hasPrimaryLocation W26196813841 @default.
- W2619681384 hasRelatedWork W12595381 @default.
- W2619681384 hasRelatedWork W172594671 @default.
- W2619681384 hasRelatedWork W2016831274 @default.
- W2619681384 hasRelatedWork W2065131845 @default.
- W2619681384 hasRelatedWork W2317243404 @default.
- W2619681384 hasRelatedWork W231923922 @default.