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- W2619725081 abstract "The solubilities of cilostazol in aqueous solutions containing polyethylene glycol 4000 (PEG 4000), polyethylene glycol 6000 (PEG 6000), polyvinylpyrrolidone K30 (PVP K30), and poly(1-vinylpyrrolidone-co-vinyl acetate) (PVP/VA) are measured at temperatures ranging from 298.15 to 318.15 K. It increased with the increase in the hydrophilic carrier concentration and temperature. PVP/VA was the most effective polymer to solubilize cilostazol. The transfer Gibbs free energy (ΔtrG°) and enthalpy (ΔtrH°) values were negative, indicating that the transfer of cilostazol from only water to an aqueous hydrophilic polymer solution is spontaneous and energetically favorable. Furthermore, the ΔtrG° and ΔtrH° values decreased with the increase in the hydrophilic polymer concentration, indicating that solubilization is more favorable with the increase in the hydrophilic polymer concentrations. In particular, the ΔtrG° values considerably decreased for PVP/VA compared to PEG 4000, PEG 6000, and PVP K30. This result indicated that PVP/VA is an effective solubilizing additive for developing oral solid formulations of cilostazol." @default.
- W2619725081 created "2017-06-05" @default.
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- W2619725081 date "2017-10-01" @default.
- W2619725081 modified "2023-10-18" @default.
- W2619725081 title "Solubility of cilostazol in the presence of polyethylene glycol 4000, polyethylene glycol 6000, polyvinylpyrrolidone K30, and poly(1-vinylpyrrolidone-co-vinyl acetate) at different temperatures" @default.
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- W2619725081 doi "https://doi.org/10.1016/j.jct.2017.05.040" @default.
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