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- W2619727047 abstract "Abstract During a proteolytically-driven maturation process, the orthoretroviral capsid protein (CA) assembles to form the convex shell that surrounds the viral genome. In some orthoretroviruses, including Rous Sarcoma Virus (RSV), CA carries a short and hydrophobic spacer peptide (SP) at its C-terminus early in the maturation process, which is progressively removed as maturation proceeds. In this work, we show that RSV CA assembles in vitro at near-physiological temperatures, forming hexamer tubes that effectively model the mature capsid surface. Tube assembly is strongly influenced by electrostatic effects, and is a nucleated process that remains thermodynamically favored at lower temperatures, but is effectively arrested by the large Gibbs energy barrier associated with nucleation. RSV CA tubes are multi-layered, being formed by nested and concentric tubes of capsid hexamers. However the spacer peptide acts as a layering determinant during tube assembly. If only a minor fraction of CA-SP is present, multi-layered tube formation is blocked, and single-layered tubes predominate. This likely prevents formation of biologically aberrant multi-layered capsids in the virion. The generation of single-layered hexamer tubes facilitated 3D helical image reconstruction from cryo-electron microscopy data, revealing the basic tube architecture." @default.
- W2619727047 created "2017-06-05" @default.
- W2619727047 creator A5011729658 @default.
- W2619727047 creator A5024108946 @default.
- W2619727047 creator A5044993402 @default.
- W2619727047 creator A5056815378 @default.
- W2619727047 creator A5057938525 @default.
- W2619727047 creator A5068002588 @default.
- W2619727047 date "2017-06-06" @default.
- W2619727047 modified "2023-10-17" @default.
- W2619727047 title "In vitro assembly of the Rous Sarcoma Virus capsid protein into hexamer tubes at physiological temperature" @default.
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