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• W2619785488 abstract "Background . Association of thyroid dysfunction (TD) with interferon treatment of HCV is well known to clinicians. However, a few studies have highlighted the role of hepatitis C virus per se in the development of TD. The aim of this study was to know the prevalence of TD in non-interferon treated HCV infected patients referred for thyroid function testing. Patients and Methods . Among 557 ELISA-positive HCV patients 446 (341 females, 105 males) were selected for this study. Serums FT 4 , FT 3 , and TSH were determined by radioimmunoassay method. Results . TD was detected in 15.2% of patients: 9.0% hypothyroidism and 6.3% hyperthyroidism. In increasing order subclinical hypothyroidism, overt hypothyroidism, overt hyperthyroidism, and subclinical hyperthyroidism were found in 4.7%, 4.3%, 3.6%, and 2.7% patients, respectively. Overall TD was more common in female than in male HCV patients but the difference was not significant (16.1% versus 12.4%;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.648</mml:mn></mml:math>). Hyperthyroidism and subclinical hypothyroidism were slightly more common in female and overall hypothyroidism and overt hypothyroidism in male patients but the difference was not statistically significant (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>p</mml:mi><mml:mo>></mml:mo><mml:mn fontstyle=italic>0.05</mml:mn></mml:math>). The incidence of TD was relatively high in patients above 36 years (median age) but the difference was not statistically significant either collectively or in gender base groups (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>p</mml:mi><mml:mo>></mml:mo><mml:mn fontstyle=italic>0.05</mml:mn></mml:math>). Conclusion . Prior to interferon treatment, HCV infection itself causes biochemical thyroid dysfunction in 15.2% of local HCV patients." @default.
• W2619785488 created "2017-06-05" @default.
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• W2619785488 date "2017-01-01" @default.
• W2619785488 modified "2023-09-29" @default.
• W2619785488 title "Thyroid Dysfunction in Non-Interferon Treated Hepatitis C Patients Residing in Hepatitis Endemic Area" @default.
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• W2619785488 doi "https://doi.org/10.1155/2017/2390812" @default.
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