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• W2619868510 abstract "Abstract Hydrocephalus, a condition in which the structure of the brain is distorted and its blood supply curtailed, is caused by accumulation of cerebrospinal fluid (CSF), usually the result of obstruction. Temporary management of the raised pressure involves the insertion of a catheter into the ventricles and drainage of CSF into a bag at the bedside external ventricular drainage (EVD). Long-term management is accomplished by the insertion of a shunt, consisting of a silicone catheter and a valve to control the rate and direction of flow, draining CSF into a body cavity, usually the abdomen. Infection involving the shunt or EVD catheters is a major complication. Bacterial biofilm development inside the catheters leads to failure of antibiotic treatment and removal of the device. Many attempts have been made to reduce the rate of infection, but recently antimicrobial catheters have been used with some success. The key to this is the use of an impregnation process rather than a coating, the former allowing maintenance of a fully active antimicrobial boundary layer for many days in flow conditions. Clinically predictive in vitro evaluation of antimicrobial catheters is demanding and expensive. Clinical experience with antimicrobial shunts shows their benefit, but there is insufficient experience with antimicrobial EVDs to confirm the early promising findings." @default.
• W2619868510 created "2017-06-05" @default.
• W2619868510 creator A5063871353 @default.
• W2619868510 date "2017-01-01" @default.
• W2619868510 modified "2023-09-22" @default.
• W2619868510 title "7.30 Cerebrospinal Fluid Shunts ☆" @default.
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• W2619868510 doi "https://doi.org/10.1016/b978-0-12-803581-8.10083-9" @default.
• W2619868510 hasPublicationYear "2017" @default.
• W2619868510 type Work @default.
• W2619868510 sameAs 2619868510 @default.

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