FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2619945698> ?p ?o ?g. }

• W2619945698 endingPage "830" @default.
• W2619945698 startingPage "830" @default.
• W2619945698 abstract "<h3>Importance</h3> Presently, the clinical standard for reporting the results of an amyloid positron emission tomography scan is to assign a dichotomous rating of positive or negative for the presence of amyloid. In a 4-year longitudinal study, we investigated whether using a continuous measure of the magnitude of baseline amyloid burden would provide valuable information about the rate of future cognitive decline over the subsequent 4 years compared with a dichotomous measure in middle-aged and older adults. <h3>Objective</h3> To examine whether a continuous, dose-response relationship between amyloid burden and cognitive decline was present among middle-aged and older adults. <h3>Design, Setting, and Participants</h3> This cohort study included 174 participants from the Dallas Lifespan Brain Study who were 40 to 89 years old at the beginning of the study, were cognitively normal at baseline (a Mini-Mental State Examination score of 26 or higher) with no history of neurological or psychiatric disorders, and had completed amyloid imaging ([¹⁸F]-florbetapir) at baseline and cognitive assessments at baseline and a 4-year follow-up. Continuous amyloid burden was measured as the mean cortical standardized uptake value ratio (SUVR) at baseline. <h3>Main Outcomes and Measures</h3> Linear mixed models assessed the effect of increasing baseline amyloid over time (SUVR × time interaction) on episodic memory, reasoning, processing speed, vocabulary, and Mini-Mental State Examination performance. Age, sex, education, apolipoprotein ε4, and the random effect of intercepts were included as covariates. <h3>Results</h3> The mean (SD) age for all participants (n = 174) was 66.44 (11.74) years, and 65 participants (37%) were men. The primary analyses yielded significant SUVR × time interactions in episodic memory, processing speed, vocabulary, and Mini-Mental State Examination performance, but not in reasoning performance. Higher baseline SUVR projected greater cognitive decline over 4 years. When controlling for variance related to a dichotomized positive/negative classification, most effects on cognition remained. Dichotomized amyloid status alone yielded fewer significant effects of amyloid on cognitive decline than continuous SUVR. Among amyloid-positive participants, increasing baseline SUVR predicted an increasing decline in episodic memory, but other effects on cognition were more limited. Finally, higher baseline amyloid burden among middle-aged adults was related to changes in vocabulary, with the effect driven by 3 apolipoprotein ε4 homozygotes. <h3>Conclusions and Relevance</h3> These results suggest that the magnitude of amyloid burden at baseline is associated with the rate of cognitive decline over 4 years and potentially provides important information about the rate of future cognitive decline that is not available from a dichotomous positive/negative categorization." @default.
• W2619945698 created "2017-06-05" @default.
• W2619945698 creator A5003042664 @default.
• W2619945698 creator A5006991707 @default.
• W2619945698 creator A5032122607 @default.
• W2619945698 creator A5034666038 @default.
• W2619945698 creator A5036709118 @default.
• W2619945698 creator A5051058343 @default.
• W2619945698 creator A5059731976 @default.
• W2619945698 creator A5069407516 @default.
• W2619945698 creator A5070439658 @default.
• W2619945698 creator A5075845832 @default.
• W2619945698 date "2017-07-01" @default.
• W2619945698 modified "2023-09-25" @default.
• W2619945698 title "Association of Longitudinal Cognitive Decline With Amyloid Burden in Middle-aged and Older Adults" @default.
• W2619945698 cites W1514102066 @default.
• W2619945698 cites W1695738173 @default.
• W2619945698 cites W1973526765 @default.
• W2619945698 cites W1975699010 @default.
• W2619945698 cites W1978684823 @default.
• W2619945698 cites W1987110004 @default.
• W2619945698 cites W1998633319 @default.
• W2619945698 cites W1999367055 @default.
• W2619945698 cites W2000759154 @default.
• W2619945698 cites W2002776021 @default.
• W2619945698 cites W2003428745 @default.
• W2619945698 cites W2010021812 @default.
• W2619945698 cites W2011195206 @default.
• W2619945698 cites W2025642774 @default.
• W2619945698 cites W2037403969 @default.
• W2619945698 cites W2047587201 @default.
• W2619945698 cites W2053395355 @default.
• W2619945698 cites W2063142549 @default.
• W2619945698 cites W2075348467 @default.
• W2619945698 cites W2079493264 @default.
• W2619945698 cites W2087011519 @default.
• W2619945698 cites W2092932101 @default.
• W2619945698 cites W2101135654 @default.
• W2619945698 cites W2109683824 @default.
• W2619945698 cites W2113319997 @default.
• W2619945698 cites W2129497119 @default.
• W2619945698 cites W2134711807 @default.
• W2619945698 cites W2148726987 @default.
• W2619945698 cites W2151721316 @default.
• W2619945698 cites W2151986002 @default.
• W2619945698 cites W2167840686 @default.
• W2619945698 cites W2174753847 @default.
• W2619945698 cites W2174862691 @default.
• W2619945698 cites W2341604488 @default.
• W2619945698 cites W2473313434 @default.
• W2619945698 cites W2521566269 @default.
• W2619945698 cites W4255838236 @default.
• W2619945698 doi "https://doi.org/10.1001/jamaneurol.2017.0892" @default.
• W2619945698 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5710531" @default.
• W2619945698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28558099" @default.
• W2619945698 hasPublicationYear "2017" @default.
• W2619945698 type Work @default.
• W2619945698 sameAs 2619945698 @default.
• W2619945698 citedByCount "83" @default.
• W2619945698 countsByYear W26199456982017 @default.
• W2619945698 countsByYear W26199456982018 @default.
• W2619945698 countsByYear W26199456982019 @default.
• W2619945698 countsByYear W26199456982020 @default.
• W2619945698 countsByYear W26199456982021 @default.
• W2619945698 countsByYear W26199456982022 @default.
• W2619945698 countsByYear W26199456982023 @default.
• W2619945698 crossrefType "journal-article" @default.
• W2619945698 hasAuthorship W2619945698A5003042664 @default.
• W2619945698 hasAuthorship W2619945698A5006991707 @default.
• W2619945698 hasAuthorship W2619945698A5032122607 @default.
• W2619945698 hasAuthorship W2619945698A5034666038 @default.
• W2619945698 hasAuthorship W2619945698A5036709118 @default.
• W2619945698 hasAuthorship W2619945698A5051058343 @default.
• W2619945698 hasAuthorship W2619945698A5059731976 @default.
• W2619945698 hasAuthorship W2619945698A5069407516 @default.
• W2619945698 hasAuthorship W2619945698A5070439658 @default.
• W2619945698 hasAuthorship W2619945698A5075845832 @default.
• W2619945698 hasBestOaLocation W26199456982 @default.
• W2619945698 hasConcept C118552586 @default.
• W2619945698 hasConcept C126322002 @default.
• W2619945698 hasConcept C142724271 @default.
• W2619945698 hasConcept C15744967 @default.
• W2619945698 hasConcept C169900460 @default.
• W2619945698 hasConcept C201903717 @default.
• W2619945698 hasConcept C2775842073 @default.
• W2619945698 hasConcept C2777895361 @default.
• W2619945698 hasConcept C2779077818 @default.
• W2619945698 hasConcept C2779134260 @default.
• W2619945698 hasConcept C2779483572 @default.
• W2619945698 hasConcept C2781073650 @default.
• W2619945698 hasConcept C2984863031 @default.
• W2619945698 hasConcept C2984915365 @default.
• W2619945698 hasConcept C2989005 @default.
• W2619945698 hasConcept C548259974 @default.
• W2619945698 hasConcept C71924100 @default.
• W2619945698 hasConcept C72563966 @default.
• W2619945698 hasConcept C74909509 @default.
• W2619945698 hasConceptScore W2619945698C118552586 @default.

• next