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- W2619953613 abstract "Organic selenium and tellurium compounds are known for their broad-spectrum effects in a variety of experimental disease models. However, these compounds commonly display high toxicity and the molecular mechanisms underlying these deleterious effects have yet to be elucidated. Thus, the need for an animal model that is inexpensive, amenable to high-throughput analyses, and feasible for molecular studies is highly desirable to improve organochalcogen pharmacological and toxicological characterization. Herein, we use Caenorhabdtis elegans (C. elegans) as a model for the assessment of pharmacological and toxicological parameters following exposure to two 4-phenylchalcogenil-7-chloroquinolines derivatives (PSQ for selenium and PTQ for tellurium-containing compounds). While non-lethal concentrations (NLC) of PTQ and PSQ attenuated paraquat-induced effects on survival, lifespan and oxidative stress parameters, lethal concentrations (LC) of PTQ and PSQ alone are able to impair these parameters in C. elegans. We also demonstrate that DAF-16/FOXO and SKN-1/Nrf2 transcription factors underlie the mechanism of action of these compounds, as their targets sod-3, gst-4 and gcs-1 were modulated following exposures in a daf-16- and skn-1-dependent manner. Finally, in accordance with a disturbed thiol metabolism in both LC and NLC, we found higher sensitivity of trxr-1 worm mutants (lacking the selenoprotein thioredoxin reductase 1) when exposed to PSQ. Finally, our study suggests new targets for the investigation of organochalcogen pharmacological effects, reinforcing the use of C. elegans as a powerful platform for preclinical approaches." @default.
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- W2619953613 date "2017-09-01" @default.
- W2619953613 modified "2023-10-16" @default.
- W2619953613 title "Insights into the differential toxicological and antioxidant effects of 4-phenylchalcogenil-7-chloroquinolines in Caenorhabditis elegans" @default.
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- W2619953613 cites W1587909744 @default.
- W2619953613 cites W1877188956 @default.
- W2619953613 cites W1944127002 @default.
- W2619953613 cites W1952455747 @default.
- W2619953613 cites W1965957522 @default.
- W2619953613 cites W1970035510 @default.
- W2619953613 cites W1971059223 @default.
- W2619953613 cites W1974183873 @default.
- W2619953613 cites W1980429333 @default.
- W2619953613 cites W1983310681 @default.
- W2619953613 cites W1986584051 @default.
- W2619953613 cites W1987973555 @default.
- W2619953613 cites W1989596556 @default.
- W2619953613 cites W1989953524 @default.
- W2619953613 cites W1995602802 @default.
- W2619953613 cites W1996053878 @default.
- W2619953613 cites W1999616259 @default.
- W2619953613 cites W2001532612 @default.
- W2619953613 cites W2006044829 @default.
- W2619953613 cites W2006370393 @default.
- W2619953613 cites W2009496604 @default.
- W2619953613 cites W2015470613 @default.
- W2619953613 cites W2017689782 @default.
- W2619953613 cites W2019713999 @default.
- W2619953613 cites W2020108617 @default.
- W2619953613 cites W2022487606 @default.
- W2619953613 cites W2023427211 @default.
- W2619953613 cites W2023431124 @default.
- W2619953613 cites W2024562943 @default.
- W2619953613 cites W2025093655 @default.
- W2619953613 cites W2025436837 @default.
- W2619953613 cites W2032306298 @default.
- W2619953613 cites W2033475624 @default.
- W2619953613 cites W2033745200 @default.
- W2619953613 cites W2041430974 @default.
- W2619953613 cites W2041946801 @default.
- W2619953613 cites W2045218894 @default.
- W2619953613 cites W2064435773 @default.
- W2619953613 cites W2065271237 @default.
- W2619953613 cites W2065297466 @default.
- W2619953613 cites W2067114364 @default.
- W2619953613 cites W2072595175 @default.
- W2619953613 cites W2080655713 @default.
- W2619953613 cites W2083637095 @default.
- W2619953613 cites W2083866681 @default.
- W2619953613 cites W2083882252 @default.
- W2619953613 cites W2084004698 @default.
- W2619953613 cites W2086257151 @default.
- W2619953613 cites W2090189011 @default.
- W2619953613 cites W2091669203 @default.
- W2619953613 cites W2093968916 @default.
- W2619953613 cites W2098567793 @default.
- W2619953613 cites W2100123437 @default.
- W2619953613 cites W2100509229 @default.
- W2619953613 cites W2111075771 @default.
- W2619953613 cites W2139269338 @default.
- W2619953613 cites W2149585271 @default.
- W2619953613 cites W2195404438 @default.
- W2619953613 cites W2207807949 @default.
- W2619953613 cites W2313691205 @default.
- W2619953613 cites W2314417470 @default.
- W2619953613 cites W2329324039 @default.
- W2619953613 cites W2338002146 @default.
- W2619953613 cites W2369417160 @default.
- W2619953613 cites W2399714449 @default.
- W2619953613 cites W2407890715 @default.
- W2619953613 cites W4229676100 @default.
- W2619953613 cites W4229935786 @default.
- W2619953613 cites W779172143 @default.
- W2619953613 doi "https://doi.org/10.1016/j.freeradbiomed.2017.05.020" @default.
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