FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2619983459> ?p ?o ?g. }

• W2619983459 endingPage "97" @default.
• W2619983459 startingPage "75" @default.
• W2619983459 abstract "This review describes the clinical and basic research that led to the description of Flammer syndrome. It is narrated from a personal perspective. This research was initiated by the observation of an increased long-term fluctuation of visual fields in a subgroup of glaucoma patients. As these patients had strikingly cold hands, peripheral blood flow was tested with a capillary microscopy, and vasospastic syndrome (VS) was diagnosed. Further studies on these patients revealed frequently weakened autoregulation of ocular blood flow and increased flow resistivity in retroocular vessels. Their retinal vessels were more rigid and irregular and responded less to flickering light. Holistic investigation demonstrated low blood pressure, silent myocardial ischaemia, altered beat-to-beat variation, altered gene expression in the lymphocytes, slightly increased plasma endothelin level and increased systemic oxidative stress. This combination of signs and symptoms was better described by the term primary vascular dysregulation (PVD) than by VS. Subsequent studies showed additional symptoms frequently related to PVD, such as low body mass index, cold extremities combined with slightly increased core temperature, prolonged sleep onset time, reduced feelings of thirst, increased sensitivity to smell and also for certain drugs and increased retinal venous pressure. To better characterise this entire syndrome, the term Flammer syndrome (FS) was introduced. Most subjects with FS were healthy. Nevertheless, FS seemed to increase the risk for certain eye diseases, particularly in younger patients. This included normal-tension glaucoma, anterior ischaemic optic neuropathy, retinal vein occlusions, Susac syndrome and central serous chorioretinopathy. Hereditary diseases, such as Leber's optic neuropathy or retinitis pigmentosa, were also associated with FS, and FS symptoms and sings occurred more frequent in patients with multiple sclerosis or with acute hearing loss. Further research should lead to a more concise definition of FS, a precise diagnosis and tools for recognizing people at risk for associated diseases. This may ultimately lead to more efficient and more personalised treatment." @default.
• W2619983459 created "2017-06-05" @default.
• W2619983459 creator A5066802902 @default.
• W2619983459 creator A5067022590 @default.
• W2619983459 date "2017-05-22" @default.
• W2619983459 modified "2023-10-14" @default.
• W2619983459 title "The discovery of the Flammer syndrome: a historical and personal perspective" @default.
• W2619983459 cites W114492904 @default.
• W2619983459 cites W116830791 @default.
• W2619983459 cites W120003126 @default.
• W2619983459 cites W1235683204 @default.
• W2619983459 cites W129657699 @default.
• W2619983459 cites W144710642 @default.
• W2619983459 cites W1500696145 @default.
• W2619983459 cites W1514191528 @default.
• W2619983459 cites W155693203 @default.
• W2619983459 cites W1557940907 @default.
• W2619983459 cites W1562730635 @default.
• W2619983459 cites W1584298527 @default.
• W2619983459 cites W1604615385 @default.
• W2619983459 cites W160589812 @default.
• W2619983459 cites W161837157 @default.
• W2619983459 cites W162670361 @default.
• W2619983459 cites W1642918513 @default.
• W2619983459 cites W164803585 @default.
• W2619983459 cites W165387345 @default.
• W2619983459 cites W166100781 @default.
• W2619983459 cites W166643756 @default.
• W2619983459 cites W170626715 @default.
• W2619983459 cites W170929439 @default.
• W2619983459 cites W1733949317 @default.
• W2619983459 cites W1754930959 @default.
• W2619983459 cites W1822064518 @default.
• W2619983459 cites W1897709198 @default.
• W2619983459 cites W191010627 @default.
• W2619983459 cites W1963965036 @default.
• W2619983459 cites W1964908577 @default.
• W2619983459 cites W1966085822 @default.
• W2619983459 cites W1967643067 @default.
• W2619983459 cites W1967802923 @default.
• W2619983459 cites W1967952216 @default.
• W2619983459 cites W1968169594 @default.
• W2619983459 cites W1968519980 @default.
• W2619983459 cites W1968559153 @default.
• W2619983459 cites W1968597772 @default.
• W2619983459 cites W1969345289 @default.
• W2619983459 cites W1970635548 @default.
• W2619983459 cites W1971397727 @default.
• W2619983459 cites W1973648197 @default.
• W2619983459 cites W1973959623 @default.
• W2619983459 cites W1974952476 @default.
• W2619983459 cites W1975361674 @default.
• W2619983459 cites W1976618691 @default.
• W2619983459 cites W1976816273 @default.
• W2619983459 cites W1977977999 @default.
• W2619983459 cites W1979762855 @default.
• W2619983459 cites W1980655887 @default.
• W2619983459 cites W198224429 @default.
• W2619983459 cites W1982920647 @default.
• W2619983459 cites W1983889134 @default.
• W2619983459 cites W1984008165 @default.
• W2619983459 cites W1984458231 @default.
• W2619983459 cites W1985129321 @default.
• W2619983459 cites W1985847591 @default.
• W2619983459 cites W1986302520 @default.
• W2619983459 cites W1986495596 @default.
• W2619983459 cites W1987472064 @default.
• W2619983459 cites W1988112327 @default.
• W2619983459 cites W1989027689 @default.
• W2619983459 cites W1989072165 @default.
• W2619983459 cites W1989434775 @default.
• W2619983459 cites W1992460259 @default.
• W2619983459 cites W1993657476 @default.
• W2619983459 cites W1996375148 @default.
• W2619983459 cites W1996420947 @default.
• W2619983459 cites W1997396272 @default.
• W2619983459 cites W1997475373 @default.
• W2619983459 cites W1998709127 @default.
• W2619983459 cites W1998775239 @default.
• W2619983459 cites W1999267868 @default.
• W2619983459 cites W1999774499 @default.
• W2619983459 cites W2000015632 @default.
• W2619983459 cites W2000184025 @default.
• W2619983459 cites W2000790943 @default.
• W2619983459 cites W2002510999 @default.
• W2619983459 cites W2002969192 @default.
• W2619983459 cites W2003208785 @default.
• W2619983459 cites W2004518036 @default.
• W2619983459 cites W2005789210 @default.
• W2619983459 cites W2006010971 @default.
• W2619983459 cites W2007082001 @default.
• W2619983459 cites W2007456079 @default.
• W2619983459 cites W2008271332 @default.
• W2619983459 cites W2008742568 @default.
• W2619983459 cites W2009396113 @default.
• W2619983459 cites W2010123281 @default.
• W2619983459 cites W2011455016 @default.
• W2619983459 cites W2011848327 @default.

• next