FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620034449> ?p ?o ?g. }

• W2620034449 endingPage "e178" @default.
• W2620034449 startingPage "e169" @default.
• W2620034449 abstract "Background: Chronic periodontitis, one of the most prevalent oral diseases, is associated with Porphyromonas gingivalis (Pg) lipopolysaccharide (LPS) infection and has profound effects on type 2 diabetes mellitus (t2DM). Metformin, a well-known antidiabetic agent, has been reported to exert anti-inflammatory effects on various cells. This study aims to investigate the role of metformin on LPS-influenced inflammatory response in human gingival fibroblasts (HGFs). Methods: Dose-dependent additive effects of metformin on LPS-influenced HGFs were detected. Cell-counting assay was used to determine effects of metformin and LPS on viability of HGFs. Enzyme-linked immunosorbent assay and quantitative real-time polymerase chain reaction (qRT-PCR) were applied to detect levels of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in differently treated cells. Activating transcription factor-3 (ATF3) small interfering (si)RNA transfection was used to determine the mechanism of metformin action, and the transfection efficiency was observed by fluorescence microscope. Effects of ATF3 knockdown were determined by qRT-PCR and Western blot. Results: Results showed that 5 μg/mL Pg LPS and 0.1, 0.5, and 1 mM metformin exhibited no toxicity to HGFs, and metformin inhibited LPS-influenced IL-1β, IL-6, and TNF-α production in a dose-dependent manner. Metformin and LPS could synergistically facilitate ATF3 expression, and ATF3 knockdown abolished inhibitory effects of metformin on LPS-influenced inflammatory cytokine production in HGFs. Conclusion: The present study confirms that metformin suppresses LPS-enhanced IL-6, IL-1β, and TNF-α production in HGFs via increasing ATF3 expression." @default.
• W2620034449 created "2017-06-05" @default.
• W2620034449 creator A5024804950 @default.
• W2620034449 creator A5046694705 @default.
• W2620034449 creator A5060470951 @default.
• W2620034449 creator A5061633389 @default.
• W2620034449 creator A5068080767 @default.
• W2620034449 creator A5089910640 @default.
• W2620034449 date "2017-10-01" @default.
• W2620034449 modified "2023-09-23" @default.
• W2620034449 title "Metformin Inhibits <i>Porphyromonas</i> <i>gingivalis</i> Lipopolysaccharide-Influenced Inflammatory Response in Human Gingival Fibroblasts via Regulating Activating Transcription Factor-3 Expression" @default.
• W2620034449 cites W1594212912 @default.
• W2620034449 cites W1955758659 @default.
• W2620034449 cites W1971349339 @default.
• W2620034449 cites W1974055484 @default.
• W2620034449 cites W1980365273 @default.
• W2620034449 cites W1984111270 @default.
• W2620034449 cites W1986704776 @default.
• W2620034449 cites W1988488542 @default.
• W2620034449 cites W1999235557 @default.
• W2620034449 cites W2013144840 @default.
• W2620034449 cites W2013203343 @default.
• W2620034449 cites W2018767491 @default.
• W2620034449 cites W2022156965 @default.
• W2620034449 cites W2028079896 @default.
• W2620034449 cites W2033056309 @default.
• W2620034449 cites W2038358889 @default.
• W2620034449 cites W2042008937 @default.
• W2620034449 cites W2042259492 @default.
• W2620034449 cites W2054933609 @default.
• W2620034449 cites W2055210950 @default.
• W2620034449 cites W2055275053 @default.
• W2620034449 cites W2060345230 @default.
• W2620034449 cites W2063948575 @default.
• W2620034449 cites W2079692416 @default.
• W2620034449 cites W2084513141 @default.
• W2620034449 cites W2088122814 @default.
• W2620034449 cites W2088359631 @default.
• W2620034449 cites W2089819595 @default.
• W2620034449 cites W2107014487 @default.
• W2620034449 cites W2113506865 @default.
• W2620034449 cites W2118470591 @default.
• W2620034449 cites W2142504521 @default.
• W2620034449 cites W2143004078 @default.
• W2620034449 cites W2145083090 @default.
• W2620034449 cites W2145221987 @default.
• W2620034449 cites W2149602039 @default.
• W2620034449 cites W2158013083 @default.
• W2620034449 cites W2160007416 @default.
• W2620034449 cites W2169417490 @default.
• W2620034449 cites W2201274541 @default.
• W2620034449 cites W2331986186 @default.
• W2620034449 cites W2510501881 @default.
• W2620034449 cites W2518437142 @default.
• W2620034449 cites W2567809950 @default.
• W2620034449 cites W2589365290 @default.
• W2620034449 doi "https://doi.org/10.1902/jop.2017.170168" @default.
• W2620034449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28548885" @default.
• W2620034449 hasPublicationYear "2017" @default.
• W2620034449 type Work @default.
• W2620034449 sameAs 2620034449 @default.
• W2620034449 citedByCount "23" @default.
• W2620034449 countsByYear W26200344492018 @default.
• W2620034449 countsByYear W26200344492019 @default.
• W2620034449 countsByYear W26200344492020 @default.
• W2620034449 countsByYear W26200344492021 @default.
• W2620034449 countsByYear W26200344492022 @default.
• W2620034449 countsByYear W26200344492023 @default.
• W2620034449 crossrefType "journal-article" @default.
• W2620034449 hasAuthorship W2620034449A5024804950 @default.
• W2620034449 hasAuthorship W2620034449A5046694705 @default.
• W2620034449 hasAuthorship W2620034449A5060470951 @default.
• W2620034449 hasAuthorship W2620034449A5061633389 @default.
• W2620034449 hasAuthorship W2620034449A5068080767 @default.
• W2620034449 hasAuthorship W2620034449A5089910640 @default.
• W2620034449 hasConcept C104317684 @default.
• W2620034449 hasConcept C126322002 @default.
• W2620034449 hasConcept C134018914 @default.
• W2620034449 hasConcept C173396325 @default.
• W2620034449 hasConcept C17991360 @default.
• W2620034449 hasConcept C185592680 @default.
• W2620034449 hasConcept C190283241 @default.
• W2620034449 hasConcept C203014093 @default.
• W2620034449 hasConcept C22615655 @default.
• W2620034449 hasConcept C2778690821 @default.
• W2620034449 hasConcept C2778754761 @default.
• W2620034449 hasConcept C2780183776 @default.
• W2620034449 hasConcept C2780323712 @default.
• W2620034449 hasConcept C2780385504 @default.
• W2620034449 hasConcept C54009773 @default.
• W2620034449 hasConcept C54355233 @default.
• W2620034449 hasConcept C55493867 @default.
• W2620034449 hasConcept C555293320 @default.
• W2620034449 hasConcept C71924100 @default.
• W2620034449 hasConcept C77179829 @default.
• W2620034449 hasConcept C81885089 @default.
• W2620034449 hasConcept C86339819 @default.
• W2620034449 hasConcept C86803240 @default.

• next