Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620042743> ?p ?o ?g. }
- W2620042743 abstract "Human existence can be viewed as an animal in a microbial world. A healthy interaction of the human host with the microbes in and around us heavily relies on a well-functioning immune system. As development of both the microbiota and the host immune system undergo rapid changes in early life, it is not surprising that even minor alterations during this co-development can have profound consequences. Scrutiny of existing data regarding pre-, peri-, as well as early postnatal modulators of newborn microbiota indeed suggest strong associations with several immune-mediated diseases with onset far beyond the newborn period. We here summarize these data and extract overarching themes. This same effort in turn sets the stage to guide effective countermeasures, such as probiotic administration. The objective of our review is to highlight the interaction of host immune ontogeny with the developing microbiome in early life as a critical window of susceptibility for lifelong disease, as well as to identify the enormous potential to protect and promote lifelong health by specifically targeting this window of opportunity." @default.
- W2620042743 created "2017-06-05" @default.
- W2620042743 creator A5025401318 @default.
- W2620042743 creator A5031408206 @default.
- W2620042743 creator A5091336196 @default.
- W2620042743 date "2017-05-24" @default.
- W2620042743 modified "2023-10-12" @default.
- W2620042743 title "Early-Life Host–Microbiome Interphase: The Key Frontier for Immune Development" @default.
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