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- W2620043860 abstract "ABSTRACT There is a pressing need to identify more effective antiretroviral drugs for HIV-2 treatment. Here, we show that the investigational compound MK-8591 (4′-ethynyl-2-fluoro-2′-deoxyadenosine [EFdA]) is highly active against group A and B isolates of HIV-2; 50% effective concentrations [EC 50 ] for HIV-2 were, on average, 4.8-fold lower than those observed for HIV-1. MK-8591 also retains potent activity against multinucleoside-resistant HIV-2 mutants (EC 50 ≤ 11 nM). These data suggest that MK-8591 may have antiviral activity in HIV-2-infected individuals." @default.
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- W2620043860 date "2017-08-01" @default.
- W2620043860 modified "2023-10-12" @default.
- W2620043860 title "MK-8591 (4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine) Exhibits Potent Activity against HIV-2 Isolates and Drug-Resistant HIV-2 Mutants in Culture" @default.
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- W2620043860 doi "https://doi.org/10.1128/aac.00744-17" @default.
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