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- W2620121042 abstract "The early phase of inflammation is characterized by the release of cytokines/chemokines from activated neutrophils, monocytes and dendritic cells. One of the most strongly secreted cytokines is the interleukin-6-type cytokine oncostatin M (OSM). Since OSM itself is a strong inducer of chemokines, particularly in tissue-resident cell types like fibroblasts, it is considered to promote the inflammatory response. Surprisingly, it has recently been shown to execute protective functions in high-fat diet-induced obesity and related metabolic disorders in mice. Its role in the development of non-alcoholic fatty liver disease (NAFLD) and in conjunction with hypercholesterolemia, however, has not been addressed so far." @default.
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- W2620121042 date "2015-12-14" @default.
- W2620121042 modified "2023-09-27" @default.
- W2620121042 title "Deficiency of the oncostatin M receptor affects the pathogenesis of non-alcoholic fatty liver disease in a context dependent manner" @default.
- W2620121042 doi "https://doi.org/10.1055/s-0035-1568022" @default.
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