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• W2620121046 abstract "Background: During lead identification and optimization, the advancement criteria may be driven based on scientific principles, prior experiences, and/or by examining the path paved by approved drugs. However, accessing the discovery data on physicochemical and ADME properties of the approved kinase inhibitors is a monumental task as these are either scattered in the literature or have not been published. Objective: Our goals were: 1) To compile the relevant data on all kinase inhibitors approved prior to 2016 for easy access by the biopharmaceutical community, 2) To provide a retrospective analysis to highlight trends and attributes which may have contributed to the developability” of these drugs, and 3) To ignite focused debates on what constitutes “actionable”, “nice-to-have”, and unnecessary data. Such debates bring about more clarity on stage appropriateness of different types of information and prevent confusion due to abundance of unnecessary data, leading to more efficient and less costly drug discovery programs. Methods: A careful and thorough analysis of different bodies of data such as published manuscripts, and available regulatory documents were employed. Results: We were able to assemble a large body of data on the first thirty kinase inhibitors approved by US FDA since 2001. Conclusion: In conclusion, we have compiled physicochemical and ADME data on the first 30 approved kinase inhibitors and provided our retrospective analysis, which we hope is helpful in constructing advancement criteria in discovery programs. The examination of this data provides an opportunity to develop an opinion on data prioritization and stage appropriateness of assays. Keywords: Kinase, inhibitor, drug, ADME, physicochemical, discovery, approved, FDA, druggability." @default.
• W2620121046 created "2017-06-05" @default.
• W2620121046 creator A5025770930 @default.
• W2620121046 creator A5080816013 @default.
• W2620121046 date "2017-10-04" @default.
• W2620121046 modified "2023-09-25" @default.
• W2620121046 title "A Systematic Analysis of Physicochemical and ADME Properties of All Small Molecule Kinase Inhibitors Approved by US FDA from January 2001 to October 2015" @default.
• W2620121046 cites W1501199419 @default.
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• W2620121046 cites W152943885 @default.
• W2620121046 cites W1576399086 @default.
• W2620121046 cites W1594189146 @default.
• W2620121046 cites W1608710587 @default.
• W2620121046 cites W1639582946 @default.
• W2620121046 cites W1672361673 @default.
• W2620121046 cites W175200875 @default.
• W2620121046 cites W1895187576 @default.
• W2620121046 cites W1897633092 @default.
• W2620121046 cites W1978572651 @default.
• W2620121046 cites W1983480353 @default.
• W2620121046 cites W1983866573 @default.
• W2620121046 cites W1988586881 @default.
• W2620121046 cites W1994830891 @default.
• W2620121046 cites W1995930366 @default.
• W2620121046 cites W1997639391 @default.
• W2620121046 cites W1998593414 @default.
• W2620121046 cites W2000379995 @default.
• W2620121046 cites W2007311407 @default.
• W2620121046 cites W2012978969 @default.
• W2620121046 cites W2013536577 @default.
• W2620121046 cites W2020459598 @default.
• W2620121046 cites W2023568503 @default.
• W2620121046 cites W2025594462 @default.
• W2620121046 cites W2030205108 @default.
• W2620121046 cites W2032353075 @default.
• W2620121046 cites W2050568471 @default.
• W2620121046 cites W2053286013 @default.
• W2620121046 cites W2053310263 @default.
• W2620121046 cites W2055236806 @default.
• W2620121046 cites W2055380229 @default.
• W2620121046 cites W2057597891 @default.
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• W2620121046 cites W2093197708 @default.
• W2620121046 cites W2093691792 @default.
• W2620121046 cites W2100105805 @default.
• W2620121046 cites W2105649494 @default.
• W2620121046 cites W2112754885 @default.
• W2620121046 cites W2115524556 @default.
• W2620121046 cites W2115794988 @default.
• W2620121046 cites W2119681112 @default.
• W2620121046 cites W2121695889 @default.
• W2620121046 cites W2124212436 @default.
• W2620121046 cites W2126162318 @default.
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• W2620121046 cites W2129089861 @default.
• W2620121046 cites W2131013066 @default.
• W2620121046 cites W2131019426 @default.
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• W2620121046 cites W2135732933 @default.
• W2620121046 cites W2136701014 @default.
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• W2620121046 cites W2143535850 @default.
• W2620121046 cites W2145454199 @default.
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• W2620121046 doi "https://doi.org/10.2174/0929867324666170523124441" @default.
• W2620121046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5748879" @default.
• W2620121046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28545370" @default.
• W2620121046 hasPublicationYear "2017" @default.
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