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• W2620125073 abstract "Despite advances in treatment modalities, colon cancer (CC) is the third most common cause of cancer-related death worldwide. Subsequent unfavorable effects owing to toxicity of conventional drugs are a challenging problem associated with chemotherapy. There is noticeable concern toward site-specific/targeted delivery of chemotherapeutic drugs specifically to the affected site of the colon in a predictable and reproducible manner. However, the biggest challenge in successful drug targeting for the colon is avoidance of drug absorption and/or degradation in the upper gastrointestinal tract before the drug reaches the colon. Nanoparticles endowed with targeting abilities offer a novel approach for site-specific delivery of chemotherapeutic agents. The present review focuses on recent approaches for colon-specific drug delivery (CDDS) and aims to unveil the emerging possibilities and advances in the treatment of CC with CDDS." @default.
• W2620125073 created "2017-06-05" @default.
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• W2620125073 date "2017-08-01" @default.
• W2620125073 modified "2023-10-14" @default.
• W2620125073 title "Strategies for targeted drug delivery in treatment of colon cancer: current trends and future perspectives" @default.
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• W2620125073 doi "https://doi.org/10.1016/j.drudis.2017.05.006" @default.
• W2620125073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28545838" @default.
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