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- W2620139211 abstract "The right-handed DNA helix exhibits two major conformations, A-DNA and B-DNA, depending on the environmental conditions. The B-DNA to A-DNA (B→A) transition is sequence specific, cooperative, and reversible. The reduced water activity due to the addition of solvents like ethanol or the presence of protein or drug molecules causes B→A transition. In several biological cases, B→A transition occurs at a local level where small fragments of a long DNA sequence undergoes B→A transition. In this review, we have discussed various aspects of B→A transition such as the role of water, sequence specificity, mechanism of B→A transition, etc. The review primarily focuses on the B→A mechanism involved at a local level, and finally its connection to the global transition in theoretical and experimental studies." @default.
- W2620139211 created "2017-06-05" @default.
- W2620139211 creator A5026772468 @default.
- W2620139211 creator A5074886886 @default.
- W2620139211 date "2017-09-01" @default.
- W2620139211 modified "2023-10-17" @default.
- W2620139211 title "Understanding B-DNA to A-DNA transition in the right-handed DNA helix: Perspective from a local to global transition" @default.
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- W2620139211 doi "https://doi.org/10.1016/j.pbiomolbio.2017.05.009" @default.
- W2620139211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28576665" @default.
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