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• W2620149081 abstract "Intimate communication between neural and vascular cells is critical for normal brain development and function. Germinal matrix (GM), a key primordium for the brain reward circuitry, is unique among brain regions for its distinct pace of angiogenesis and selective vulnerability to hemorrhage during development. A major neonatal condition, GM hemorrhage can lead to cerebral palsy, hydrocephalus, and mental retardation. Here we identify a brain-region-specific neural progenitor-based signaling pathway dedicated to regulating GM vessel development. This pathway consists of cell-surface sphingosine-1-phosphate receptors, an intracellular cascade including Gα co-factor Ric8a and p38 MAPK, and target gene integrin β8, which in turn regulates vascular TGF-β signaling. These findings provide insights into region-specific specialization of neurovascular communication, with special implications for deciphering potent early-life endocrine, as well as potential gut microbiota impacts on brain reward circuitry. They also identify tissue-specific molecular targets for GM hemorrhage intervention." @default.
• W2620149081 created "2017-06-05" @default.
• W2620149081 creator A5036242139 @default.
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• W2620149081 date "2017-05-01" @default.
• W2620149081 modified "2023-10-16" @default.
• W2620149081 title "A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis" @default.
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• W2620149081 doi "https://doi.org/10.1016/j.devcel.2017.04.014" @default.
• W2620149081 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5492999" @default.
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