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- W2620180145 endingPage "20160939" @default.
- W2620180145 startingPage "20160939" @default.
- W2620180145 abstract "Oxygen distribution is a major determinant of treatment success in radiotherapy, with well-oxygenated tumour regions responding by up to a factor of three relative to anoxic volumes. Conversely, tumour hypoxia is associated with treatment resistance and negative prognosis. Tumour oxygenation is highly heterogeneous and difficult to measure directly. The recent advent of functional hypoxia imaging modalities such as fluorine-18 fluoromisonidazole positron emission tomography have shown promise in non-invasively determining regions of low oxygen tension. This raises the prospect of selectively increasing dose to hypoxic subvolumes, a concept known as dose painting. Yet while this is a promising approach, oxygen-mediated radioresistance is inherently a multiscale problem, and there are still a number of substantial challenges that must be overcome if hypoxia dose painting is to be successfully implemented. Current imaging modalities are limited by the physics of such systems to have resolutions in the millimetre regime, whereas oxygen distribution varies over a micron scale, and treatment delivery is typically modulated on a centimetre scale. In this review, we examine the mechanistic basis and implications of the radiobiological oxygen effect, the factors influencing microscopic heterogeneity in tumour oxygenation and the consequent challenges in the interpretation of clinical hypoxia imaging (in particular fluorine-18 fluoromisonidazole positron emission tomography). We also discuss dose-painting approaches and outline challenges that must be addressed to improve this treatment paradigm." @default.
- W2620180145 created "2017-06-05" @default.
- W2620180145 creator A5024764935 @default.
- W2620180145 creator A5036198112 @default.
- W2620180145 creator A5059823227 @default.
- W2620180145 date "2017-08-01" @default.
- W2620180145 modified "2023-10-10" @default.
- W2620180145 title "Hypoxia imaging and radiotherapy: bridging the resolution gap" @default.
- W2620180145 cites W1547961512 @default.
- W2620180145 cites W1557019051 @default.
- W2620180145 cites W1573363574 @default.
- W2620180145 cites W1938573150 @default.
- W2620180145 cites W1963704146 @default.
- W2620180145 cites W1964893231 @default.
- W2620180145 cites W1973173610 @default.
- W2620180145 cites W1978282308 @default.
- W2620180145 cites W1979306998 @default.
- W2620180145 cites W1980675667 @default.
- W2620180145 cites W1981171344 @default.
- W2620180145 cites W1983937835 @default.
- W2620180145 cites W1984495607 @default.
- W2620180145 cites W1984996499 @default.
- W2620180145 cites W1989783323 @default.
- W2620180145 cites W1992391893 @default.
- W2620180145 cites W1993388378 @default.
- W2620180145 cites W1994134155 @default.
- W2620180145 cites W2005277758 @default.
- W2620180145 cites W2005719624 @default.
- W2620180145 cites W2005733600 @default.
- W2620180145 cites W2006153373 @default.
- W2620180145 cites W2007207498 @default.
- W2620180145 cites W2010638294 @default.
- W2620180145 cites W2010708650 @default.
- W2620180145 cites W2012023411 @default.
- W2620180145 cites W2015001514 @default.
- W2620180145 cites W2015040789 @default.
- W2620180145 cites W2015341124 @default.
- W2620180145 cites W2015397927 @default.
- W2620180145 cites W2016550302 @default.
- W2620180145 cites W2023554081 @default.
- W2620180145 cites W2024903578 @default.
- W2620180145 cites W2026103498 @default.
- W2620180145 cites W2028107411 @default.
- W2620180145 cites W2030892741 @default.
- W2620180145 cites W2031643846 @default.
- W2620180145 cites W2033978063 @default.
- W2620180145 cites W2036730957 @default.
- W2620180145 cites W2036753927 @default.
- W2620180145 cites W2039259012 @default.
- W2620180145 cites W2043115868 @default.
- W2620180145 cites W2043897062 @default.
- W2620180145 cites W2044171475 @default.
- W2620180145 cites W2047698114 @default.
- W2620180145 cites W2048619131 @default.
- W2620180145 cites W2052489624 @default.
- W2620180145 cites W2056593067 @default.
- W2620180145 cites W2057290654 @default.
- W2620180145 cites W2061434030 @default.
- W2620180145 cites W2069240289 @default.
- W2620180145 cites W2071393494 @default.
- W2620180145 cites W2073399837 @default.
- W2620180145 cites W2077679212 @default.
- W2620180145 cites W2077899697 @default.
- W2620180145 cites W2084486398 @default.
- W2620180145 cites W2087775476 @default.
- W2620180145 cites W2088255270 @default.
- W2620180145 cites W2091206478 @default.
- W2620180145 cites W2093400737 @default.
- W2620180145 cites W2093988815 @default.
- W2620180145 cites W2094146747 @default.
- W2620180145 cites W2094300507 @default.
- W2620180145 cites W2097598171 @default.
- W2620180145 cites W2099965109 @default.
- W2620180145 cites W2101282575 @default.
- W2620180145 cites W2105332214 @default.
- W2620180145 cites W2110421195 @default.
- W2620180145 cites W2114408640 @default.
- W2620180145 cites W2118373200 @default.
- W2620180145 cites W2118981922 @default.
- W2620180145 cites W2119846994 @default.
- W2620180145 cites W2124496728 @default.
- W2620180145 cites W2126360866 @default.
- W2620180145 cites W2126810504 @default.
- W2620180145 cites W2127016094 @default.
- W2620180145 cites W2127655040 @default.
- W2620180145 cites W2127957020 @default.
- W2620180145 cites W2130443041 @default.
- W2620180145 cites W2131004438 @default.
- W2620180145 cites W2136445803 @default.
- W2620180145 cites W2136800292 @default.
- W2620180145 cites W2143208547 @default.
- W2620180145 cites W2146308184 @default.
- W2620180145 cites W2151196497 @default.
- W2620180145 cites W2155258338 @default.
- W2620180145 cites W2155993444 @default.
- W2620180145 cites W2156599555 @default.
- W2620180145 cites W2157607856 @default.
- W2620180145 cites W2160425601 @default.