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- W2620221405 abstract "AbstractMedulloblastoma is the most common childhood malignant brain tumour, and represents 20% of all paediatric central nervous system neoplasms. Although advances in surgery, radiation and chemotherapy have improved overall survival, the lifelong sequelae of these treatments represents a major health care burden for patients, parents, and society. Recent progress in the molecular subtyping of medulloblastoma have revealed at least four distinct subsets of tumours with dramatically different biology. Additionally, medulloblastoma predominately occurs in males and maleness correlates with worse outcome. However, the drivers of this sexual dimorphism in medulloblastoma are unclear. We have identified that STAT3 is one such factor. Deletion of STAT3 from granule cell precursors in a mouse model of SHh medulloblastoma driven by the loss of one PTCH1 allele results in complete protection of males, but has no effect in females. Stratification of transcriptomics data from a cohort of SHh medulloblastoma patients on the basis of STAT3 expression shows that male patients with low STAT3 expression have improved overall survival - an outcome not observed in females. Additionally, we identified STAT3-dependent genes, specific to males which correlate with overall survival. This is one of the first observations of a gene that could, in part, explain the sex dimorphism in medulloblastoma and offer insights into altered treatment options for patients on the basis of their sex and/or STAT3 expression." @default.
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- W2620221405 date "2017-05-31" @default.
- W2620221405 modified "2023-09-26" @default.
- W2620221405 title "MEDU-17. SEXUALLY DIMORPHIC ROLES OF STAT3 IN MEDULLOBLASTOMA" @default.
- W2620221405 doi "https://doi.org/10.1093/neuonc/nox083.168" @default.
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