FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620223334> ?p ?o ?g. }

• W2620223334 endingPage "91" @default.
• W2620223334 startingPage "82" @default.
• W2620223334 abstract "Recent evidence has suggested novel roles of small nucleolar RNAs (snoRNAs) in tumorigenicity. However, the roles of C/D box snoRNA U76 (SNORD76) in the development of hepatocellular carcinoma (HCC) remain unknown. Herein, we systematically evaluated dysregulation of snoRNAs in HCC and clarified the biomarker potential and biological significance of SNORD76 in HCC.We performed quantitative analyses of the expression of SNORD76 in 66 HCC specimens to compare its expression pattern between tumor tissue and matched non-tumor tissue. The effects of SNORD76 on HCC tumorigenicity were investigated in SK-Hep1 and Huh7 cells as well as in a xenograft nude mouse model.SNORD76 expression was significantly upregulated in HCC tissues compared to corresponding non-tumor tissues. This upregulation of SNORD76 in HCC tumors was significantly associated with poorer patient survival. Furthermore, inhibiting SNORD76 expression suppressed cell proliferation by inducing G0/G1 cell cycle arrest and apoptosis. Low SNORD76 expression also resulted in decreased HCC growth in an animal model. Conversely, overexpressing SNORD76 promoted cell proliferation. SNORD76 increased HCC cell invasion by inducing epithelial-mesenchymal transition (EMT). Finally, we found that SNORD76 promoted HCC tumorigenicity through activation of the Wnt/β-catenin pathway.Therefore, we demonstrated for the first time that SNORD76 may function as a novel tumor promoter in HCC and may serve as a promising prognostic biomarker in patients with HCC." @default.
• W2620223334 created "2017-06-05" @default.
• W2620223334 creator A5014384556 @default.
• W2620223334 creator A5040796539 @default.
• W2620223334 creator A5045384691 @default.
• W2620223334 creator A5074024792 @default.
• W2620223334 creator A5080951657 @default.
• W2620223334 creator A5083374325 @default.
• W2620223334 date "2018-02-01" @default.
• W2620223334 modified "2023-10-18" @default.
• W2620223334 title "Clinical significance of C/D box small nucleolar RNA U76 as an oncogene and a prognostic biomarker in hepatocellular carcinoma" @default.
• W2620223334 cites W1814192473 @default.
• W2620223334 cites W1822176298 @default.
• W2620223334 cites W1980900189 @default.
• W2620223334 cites W1992081366 @default.
• W2620223334 cites W2012372842 @default.
• W2620223334 cites W2022523272 @default.
• W2620223334 cites W2053994548 @default.
• W2620223334 cites W2063155123 @default.
• W2620223334 cites W2068542290 @default.
• W2620223334 cites W2099860095 @default.
• W2620223334 cites W2118100797 @default.
• W2620223334 cites W2120920586 @default.
• W2620223334 cites W2133635440 @default.
• W2620223334 cites W2146653515 @default.
• W2620223334 cites W2153483580 @default.
• W2620223334 cites W2166046244 @default.
• W2620223334 cites W2309086988 @default.
• W2620223334 cites W2328695752 @default.
• W2620223334 cites W2339820296 @default.
• W2620223334 cites W2366419812 @default.
• W2620223334 cites W2394559064 @default.
• W2620223334 cites W2412860764 @default.
• W2620223334 cites W2413040940 @default.
• W2620223334 cites W2460762360 @default.
• W2620223334 cites W2473101309 @default.
• W2620223334 cites W2476098136 @default.
• W2620223334 cites W2510939851 @default.
• W2620223334 cites W2518006691 @default.
• W2620223334 cites W2558011394 @default.
• W2620223334 cites W2917837889 @default.
• W2620223334 cites W4211105405 @default.
• W2620223334 cites W4245403358 @default.
• W2620223334 doi "https://doi.org/10.1016/j.clinre.2017.04.018" @default.
• W2620223334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28578939" @default.
• W2620223334 hasPublicationYear "2018" @default.
• W2620223334 type Work @default.
• W2620223334 sameAs 2620223334 @default.
• W2620223334 citedByCount "26" @default.
• W2620223334 countsByYear W26202233342018 @default.
• W2620223334 countsByYear W26202233342019 @default.
• W2620223334 countsByYear W26202233342020 @default.
• W2620223334 countsByYear W26202233342021 @default.
• W2620223334 countsByYear W26202233342022 @default.
• W2620223334 countsByYear W26202233342023 @default.
• W2620223334 crossrefType "journal-article" @default.
• W2620223334 hasAuthorship W2620223334A5014384556 @default.
• W2620223334 hasAuthorship W2620223334A5040796539 @default.
• W2620223334 hasAuthorship W2620223334A5045384691 @default.
• W2620223334 hasAuthorship W2620223334A5074024792 @default.
• W2620223334 hasAuthorship W2620223334A5080951657 @default.
• W2620223334 hasAuthorship W2620223334A5083374325 @default.
• W2620223334 hasConcept C104317684 @default.
• W2620223334 hasConcept C121608353 @default.
• W2620223334 hasConcept C126322002 @default.
• W2620223334 hasConcept C127561419 @default.
• W2620223334 hasConcept C137620995 @default.
• W2620223334 hasConcept C1491633281 @default.
• W2620223334 hasConcept C179255354 @default.
• W2620223334 hasConcept C190283241 @default.
• W2620223334 hasConcept C2778019345 @default.
• W2620223334 hasConcept C2781018059 @default.
• W2620223334 hasConcept C2781197716 @default.
• W2620223334 hasConcept C29537977 @default.
• W2620223334 hasConcept C502942594 @default.
• W2620223334 hasConcept C54355233 @default.
• W2620223334 hasConcept C55493867 @default.
• W2620223334 hasConcept C62112901 @default.
• W2620223334 hasConcept C62203573 @default.
• W2620223334 hasConcept C62478195 @default.
• W2620223334 hasConcept C71924100 @default.
• W2620223334 hasConcept C86803240 @default.
• W2620223334 hasConcept C95444343 @default.
• W2620223334 hasConceptScore W2620223334C104317684 @default.
• W2620223334 hasConceptScore W2620223334C121608353 @default.
• W2620223334 hasConceptScore W2620223334C126322002 @default.
• W2620223334 hasConceptScore W2620223334C127561419 @default.
• W2620223334 hasConceptScore W2620223334C137620995 @default.
• W2620223334 hasConceptScore W2620223334C1491633281 @default.
• W2620223334 hasConceptScore W2620223334C179255354 @default.
• W2620223334 hasConceptScore W2620223334C190283241 @default.
• W2620223334 hasConceptScore W2620223334C2778019345 @default.
• W2620223334 hasConceptScore W2620223334C2781018059 @default.
• W2620223334 hasConceptScore W2620223334C2781197716 @default.
• W2620223334 hasConceptScore W2620223334C29537977 @default.
• W2620223334 hasConceptScore W2620223334C502942594 @default.
• W2620223334 hasConceptScore W2620223334C54355233 @default.
• W2620223334 hasConceptScore W2620223334C55493867 @default.

• next