Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620232270> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2620232270 endingPage "1329" @default.
- W2620232270 startingPage "1322" @default.
- W2620232270 abstract "Abstract The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) exenatide and lixisenatide reduce cholecystokinin (CCK)‐induced gallbladder emptying in healthy subjects. It is unknown if all GLP‐1 RAs share this effect; therefore, the effect of the GLP‐1 RA albiglutide on gallbladder function was assessed. In this randomized, double‐blind, 2‐way crossover study, a single dose of subcutaneous albiglutide 50 mg or placebo was administered to 17 healthy subjects, and CCK‐induced gallbladder contractility was measured by ultrasonography. CCK (0.003 μg/kg) was infused intravenously over 50 minutes on study day 4 (3 days after dosing, to coincide with albiglutide's expected time to maximum concentration). Gallbladder volume, ejection fraction, and the main pancreatic and common bile‐duct diameters were measured before, during, and following CCK infusion. Gallbladder volume was significantly greater in the albiglutide vs placebo groups before, during, and after CCK infusion, and the mean difference from placebo increased numerically during CCK infusion. The area under the volume‐effect curve was significantly greater with albiglutide ( P = .029). Starting at the 30‐minute CCK infusion time point, the gallbladder ejection fraction was significantly lower with albiglutide than placebo. Changes in pancreatic duct diameter and common bile‐duct diameter were not significantly different between albiglutide and placebo. Similar incidences of adverse events were observed between the albiglutide and placebo treatment periods. No new albiglutide safety signals were detected, and no serious adverse events were reported. In conclusion, similar to other GLP‐1 RAs, albiglutide decreased CCK‐induced gallbladder emptying compared with placebo in healthy individuals. Clinical implications of the gallbladder effects are unclear at this time." @default.
- W2620232270 created "2017-06-05" @default.
- W2620232270 creator A5040123676 @default.
- W2620232270 creator A5042540620 @default.
- W2620232270 creator A5046687750 @default.
- W2620232270 creator A5059542109 @default.
- W2620232270 creator A5075463492 @default.
- W2620232270 creator A5081692327 @default.
- W2620232270 date "2017-05-19" @default.
- W2620232270 modified "2023-10-06" @default.
- W2620232270 title "Effect of Albiglutide on Cholecystokinin-Induced Gallbladder Emptying in Healthy Individuals: A Randomized Crossover Study" @default.
- W2620232270 cites W1724200113 @default.
- W2620232270 cites W1945841307 @default.
- W2620232270 cites W1989339210 @default.
- W2620232270 cites W2019513002 @default.
- W2620232270 cites W2023695436 @default.
- W2620232270 cites W2048290927 @default.
- W2620232270 cites W2062098402 @default.
- W2620232270 cites W2069601051 @default.
- W2620232270 cites W2114027444 @default.
- W2620232270 cites W2128825255 @default.
- W2620232270 cites W2137562839 @default.
- W2620232270 cites W2178377864 @default.
- W2620232270 cites W2261184724 @default.
- W2620232270 cites W2290082435 @default.
- W2620232270 cites W2330429556 @default.
- W2620232270 cites W2341277771 @default.
- W2620232270 cites W2498502918 @default.
- W2620232270 cites W4297846523 @default.
- W2620232270 doi "https://doi.org/10.1002/jcph.940" @default.
- W2620232270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28543352" @default.
- W2620232270 hasPublicationYear "2017" @default.
- W2620232270 type Work @default.
- W2620232270 sameAs 2620232270 @default.
- W2620232270 citedByCount "7" @default.
- W2620232270 countsByYear W26202322702018 @default.
- W2620232270 countsByYear W26202322702019 @default.
- W2620232270 countsByYear W26202322702020 @default.
- W2620232270 countsByYear W26202322702021 @default.
- W2620232270 countsByYear W26202322702023 @default.
- W2620232270 crossrefType "journal-article" @default.
- W2620232270 hasAuthorship W2620232270A5040123676 @default.
- W2620232270 hasAuthorship W2620232270A5042540620 @default.
- W2620232270 hasAuthorship W2620232270A5046687750 @default.
- W2620232270 hasAuthorship W2620232270A5059542109 @default.
- W2620232270 hasAuthorship W2620232270A5075463492 @default.
- W2620232270 hasAuthorship W2620232270A5081692327 @default.
- W2620232270 hasConcept C126322002 @default.
- W2620232270 hasConcept C142724271 @default.
- W2620232270 hasConcept C170493617 @default.
- W2620232270 hasConcept C204787440 @default.
- W2620232270 hasConcept C27081682 @default.
- W2620232270 hasConcept C2777148285 @default.
- W2620232270 hasConcept C2777593968 @default.
- W2620232270 hasConcept C71924100 @default.
- W2620232270 hasConcept C87813604 @default.
- W2620232270 hasConcept C90924648 @default.
- W2620232270 hasConceptScore W2620232270C126322002 @default.
- W2620232270 hasConceptScore W2620232270C142724271 @default.
- W2620232270 hasConceptScore W2620232270C170493617 @default.
- W2620232270 hasConceptScore W2620232270C204787440 @default.
- W2620232270 hasConceptScore W2620232270C27081682 @default.
- W2620232270 hasConceptScore W2620232270C2777148285 @default.
- W2620232270 hasConceptScore W2620232270C2777593968 @default.
- W2620232270 hasConceptScore W2620232270C71924100 @default.
- W2620232270 hasConceptScore W2620232270C87813604 @default.
- W2620232270 hasConceptScore W2620232270C90924648 @default.
- W2620232270 hasFunder F4320307773 @default.
- W2620232270 hasIssue "10" @default.
- W2620232270 hasLocation W26202322701 @default.
- W2620232270 hasLocation W26202322702 @default.
- W2620232270 hasOpenAccess W2620232270 @default.
- W2620232270 hasPrimaryLocation W26202322701 @default.
- W2620232270 hasRelatedWork W2076117661 @default.
- W2620232270 hasRelatedWork W2094259459 @default.
- W2620232270 hasRelatedWork W2132710482 @default.
- W2620232270 hasRelatedWork W2169789864 @default.
- W2620232270 hasRelatedWork W2320189936 @default.
- W2620232270 hasRelatedWork W2413878377 @default.
- W2620232270 hasRelatedWork W2472158654 @default.
- W2620232270 hasRelatedWork W2997331034 @default.
- W2620232270 hasRelatedWork W37242892 @default.
- W2620232270 hasRelatedWork W96519093 @default.
- W2620232270 hasVolume "57" @default.
- W2620232270 isParatext "false" @default.
- W2620232270 isRetracted "false" @default.
- W2620232270 magId "2620232270" @default.
- W2620232270 workType "article" @default.