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- W2620235007 abstract "5670 Carcinoma of the exocrine pancreas has a particularly poor prognosis. Five-year survival is only 3-5%. Radical pancreaticoduodenectomy, especially for minimal disease, is currently the only chance of cure. Although chemotherapy has led to improvement in survival in patients with locally advanced disease, the overall effect is small. Also, surgery or radiotherapy of locally advanced unresectable pancreatic cancer does not lead to significantly prolonged survival. Therefore, novel therapeutic strategies are required. PBI-0110 is a well-defined low molecular weight orally active molecule. PBI-0110 has been shown to induce in vitro cell cytotoxicity towards Panc02 cell line and suppress tumor growth in the intradermal and orthotopic Panc02 tumor model. The antitumor efficacy of oral administration of PBI-0110 (100 mg/kg) was studied in combination with the standard therapy, gemcitabine (iv, 50 mg/kg), in intradermal pancreatic Panc02 cancer. Mice were treated every day with oral administration of vehicle (negative control), or PBI-0110 and with intraperitoneal injection of gemcitabine (50 mg/kg) once a week. Tumors were palpable, in general, 3-5 days post-inoculation. Gemcitabine induced a significant inhibition (p" @default.
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- W2620235007 date "2008-05-01" @default.
- W2620235007 modified "2023-09-25" @default.
- W2620235007 title "Anticancer effect of PBI-0110 in combination with gemcitabine in intradermal and orthotopic pancreatic cancer" @default.
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