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• W2620235300 abstract "Abstract Introduction To assess laryngeal motion in early glottic cancer in order to determine safe margins for partial larynx volumetric modulated arc therapy (PL‐VMAT), and to quantify dosimetric advantages of PL‐VMAT. Methods This prospective study included T1‐2N0 glottic cancers treated with whole larynx VMAT (WL‐VMAT). Pre‐ and mid‐treatment 4D‐computed tomography (4D‐CT) and dynamic magnetic resonance imaging (MRI) allowed for assessment of larynx swallowing and respiratory motion. For 10 patients with lateralized lesions, PL‐VMAT plans were calculated using margins derived from 4D‐CT analysis. Results Twenty patients were accrued from 2014 to 2016. Mean amplitude of larynx swallowing excursion was 23 mm and 6 mm in the superior and anterior directions, respectively. Mean respiratory motion reached 4 mm and 2 mm in superior‐inferior and antero‐posterior directions, respectively. Pre‐treatment 4D‐CT analysis identified one patient with planning CT acquired during swallowing. Mid‐treatment 4D‐CT revealed larynx shift relative to vertebrae in 30% of cases. PL‐VMAT allowed for significant reduction of mean doses to ipsilateral carotid, contralateral carotid, thyroid gland, contralateral arytenoid and larynx. Using 8 mm internal margin for PL‐VMAT, swallowing resulted in clinical target volume excursion beyond 95% isodose line during ≤1.5% of total treatment time in all patients. Conclusion Although swallowing motion is rare, rapid and easily suppressed by patients, there is a risk of systematic miss‐targeting if planning CT is acquired during swallowing. Larynx position shift relative to vertebrae occurs in 1/3 of patients over the course of radiotherapy. With soft‐tissue image guidance and margins accounting for respiratory motion, PL‐VMAT allows safe reduction of dose to organs at risk." @default.
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• W2620235300 date "2017-05-30" @default.
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• W2620235300 title "Larynx motion considerations in partial larynx volumetric modulated arc therapy for early glottic cancer" @default.
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• W2620235300 doi "https://doi.org/10.1111/1754-9485.12612" @default.
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