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• W2620295621 endingPage "588" @default.
• W2620295621 startingPage "572" @default.
• W2620295621 abstract "The bacterial flagellar export switching machinery consists of a ruler protein, FliK, and an export switch protein, FlhB and switches substrate specificity of the flagellar type III export apparatus upon completion of hook assembly. An interaction between the C-terminal domain of FliK (FliKC ) and the C-terminal cytoplasmic domain of FlhB (FlhBC ) is postulated to be responsible for this switch. FliKC has a compactly folded domain termed FliKT3S4 (residues 268-352) and an intrinsically disordered region composed of the last 53 residues, FliKCT (residues 353-405). Residues 301-350 of FliKT3S4 and the last five residues of FliKCT are critical for the switching function of FliK. FliKCT is postulated to regulate the interaction of FliKT3S4 with FlhBC , but it remains unknown how. Here we report the role of FliKCT in the export switching mechanism. Systematic deletion analyses of FliKCT revealed that residues of 351-370 are responsible for efficient switching of substrate specificity of the export apparatus. Suppressor mutant analyses showed that FliKCT coordinates FliKT3S4 action with the switching. Site-directed photo-cross-linking experiments showed that Val-302 and Ile-304 in the hydrophobic core of FliKT3S4 bind to FlhBC . We propose that FliKCT may induce conformational rearrangements of FliKT3S4 to bind to FlhBC ." @default.
• W2620295621 created "2017-06-05" @default.
• W2620295621 creator A5025152584 @default.
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• W2620295621 creator A5078668392 @default.
• W2620295621 creator A5087873662 @default.
• W2620295621 date "2017-06-15" @default.
• W2620295621 modified "2023-10-10" @default.
• W2620295621 title "The role of intrinsically disordered C‐terminal region of FliK in substrate specificity switching of the bacterial flagellar type III export apparatus" @default.
• W2620295621 cites W1513333509 @default.
• W2620295621 cites W1531558946 @default.
• W2620295621 cites W1536775120 @default.
• W2620295621 cites W1566222266 @default.
• W2620295621 cites W1567074356 @default.
• W2620295621 cites W1586568504 @default.
• W2620295621 cites W1687068698 @default.
• W2620295621 cites W1883110457 @default.
• W2620295621 cites W1901048275 @default.
• W2620295621 cites W1931849326 @default.
• W2620295621 cites W1965453062 @default.
• W2620295621 cites W1965912722 @default.
• W2620295621 cites W1983277607 @default.
• W2620295621 cites W1985163825 @default.
• W2620295621 cites W1986826865 @default.
• W2620295621 cites W1991831438 @default.
• W2620295621 cites W1994729386 @default.
• W2620295621 cites W1996151076 @default.
• W2620295621 cites W1999765917 @default.
• W2620295621 cites W2003197536 @default.
• W2620295621 cites W2009176195 @default.
• W2620295621 cites W2024251821 @default.
• W2620295621 cites W2026385451 @default.
• W2620295621 cites W2031923764 @default.
• W2620295621 cites W2034394264 @default.
• W2620295621 cites W2035729932 @default.
• W2620295621 cites W2037267568 @default.
• W2620295621 cites W2037300459 @default.
• W2620295621 cites W2040602970 @default.
• W2620295621 cites W2043981786 @default.
• W2620295621 cites W2046399932 @default.
• W2620295621 cites W2062136233 @default.
• W2620295621 cites W2062892191 @default.
• W2620295621 cites W2066105048 @default.
• W2620295621 cites W2066578497 @default.
• W2620295621 cites W2067406019 @default.
• W2620295621 cites W2067622947 @default.
• W2620295621 cites W2081350387 @default.
• W2620295621 cites W2091877974 @default.
• W2620295621 cites W2098724843 @default.
• W2620295621 cites W2099994998 @default.
• W2620295621 cites W2110071696 @default.
• W2620295621 cites W2111595188 @default.
• W2620295621 cites W2115447566 @default.
• W2620295621 cites W2116431320 @default.
• W2620295621 cites W2118479717 @default.
• W2620295621 cites W2121952882 @default.
• W2620295621 cites W2122062958 @default.
• W2620295621 cites W2125712541 @default.
• W2620295621 cites W2133366275 @default.
• W2620295621 cites W2137055458 @default.
• W2620295621 cites W2140566882 @default.
• W2620295621 cites W2145136352 @default.
• W2620295621 cites W2145588458 @default.
• W2620295621 cites W2150488049 @default.
• W2620295621 cites W2154117953 @default.
• W2620295621 cites W2164700373 @default.
• W2620295621 cites W2164905805 @default.
• W2620295621 cites W2167210281 @default.
• W2620295621 cites W2169535530 @default.
• W2620295621 cites W2170964111 @default.
• W2620295621 cites W2214123948 @default.
• W2620295621 cites W2291836267 @default.
• W2620295621 cites W2334468038 @default.
• W2620295621 cites W2401506608 @default.
• W2620295621 cites W2416231187 @default.
• W2620295621 cites W2514579469 @default.
• W2620295621 cites W2560491362 @default.
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• W2620295621 doi "https://doi.org/10.1111/mmi.13718" @default.
• W2620295621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28557186" @default.
• W2620295621 hasPublicationYear "2017" @default.
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