Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620343734> ?p ?o ?g. }
- W2620343734 abstract "Abstract DNAX accessory molecule-1 (DNAM-1, also known as CD226) is an activating receptor expressed on subsets of natural killer (NK) and T cells, interacts with its ligands CD155 or CD112, and has co-varied expression with inhibitory receptors. Since inhibitory receptors control NK-cell activation and are necessary for MHC-I-dependent education, we investigated whether DNAM-1 expression is also involved in NK-cell education. Here we show an MHC-I-dependent correlation between DNAM-1 expression and NK-cell education, and an association between DNAM-1 and NKG2A that occurs even in MHC class I deficient mice. DNAM-1 is expressed early during NK-cell development, precedes the expression of MHC-I-specific inhibitory receptors, and is modulated in an education-dependent fashion. Cd226 −/− mice have missing self-responses and NK cells with a normal receptor repertoire. We propose a model in which NK-cell education prevents or delays downregulation of DNAM-1. This molecule endows educated NK cells with enhanced effector functions but is dispensable for education." @default.
- W2620343734 created "2017-06-05" @default.
- W2620343734 creator A5002674606 @default.
- W2620343734 creator A5021331386 @default.
- W2620343734 creator A5022927127 @default.
- W2620343734 creator A5040973657 @default.
- W2620343734 creator A5048548750 @default.
- W2620343734 creator A5055691289 @default.
- W2620343734 creator A5071151109 @default.
- W2620343734 creator A5076200740 @default.
- W2620343734 creator A5088847566 @default.
- W2620343734 creator A5089051856 @default.
- W2620343734 date "2017-05-31" @default.
- W2620343734 modified "2023-10-17" @default.
- W2620343734 title "Expression of CD226 is associated to but not required for NK cell education" @default.
- W2620343734 cites W1601158190 @default.
- W2620343734 cites W1863751964 @default.
- W2620343734 cites W1892561736 @default.
- W2620343734 cites W1962349010 @default.
- W2620343734 cites W1968321644 @default.
- W2620343734 cites W1972835787 @default.
- W2620343734 cites W1974308995 @default.
- W2620343734 cites W1975465086 @default.
- W2620343734 cites W1983266259 @default.
- W2620343734 cites W1988547097 @default.
- W2620343734 cites W1989712520 @default.
- W2620343734 cites W1994888826 @default.
- W2620343734 cites W1996717063 @default.
- W2620343734 cites W1999092913 @default.
- W2620343734 cites W2004191344 @default.
- W2620343734 cites W2004923604 @default.
- W2620343734 cites W2007400263 @default.
- W2620343734 cites W2007825988 @default.
- W2620343734 cites W2017670466 @default.
- W2620343734 cites W2018642917 @default.
- W2620343734 cites W2019995256 @default.
- W2620343734 cites W2024746633 @default.
- W2620343734 cites W2039638023 @default.
- W2620343734 cites W2040423510 @default.
- W2620343734 cites W2042037279 @default.
- W2620343734 cites W2048245039 @default.
- W2620343734 cites W2048671971 @default.
- W2620343734 cites W2050962105 @default.
- W2620343734 cites W2051885016 @default.
- W2620343734 cites W2054366595 @default.
- W2620343734 cites W2060798773 @default.
- W2620343734 cites W2062713243 @default.
- W2620343734 cites W2063450738 @default.
- W2620343734 cites W2066011015 @default.
- W2620343734 cites W2067819783 @default.
- W2620343734 cites W2076248543 @default.
- W2620343734 cites W2080781820 @default.
- W2620343734 cites W2088513299 @default.
- W2620343734 cites W2096449627 @default.
- W2620343734 cites W2102236683 @default.
- W2620343734 cites W2109081619 @default.
- W2620343734 cites W2116171543 @default.
- W2620343734 cites W2127834152 @default.
- W2620343734 cites W2131625721 @default.
- W2620343734 cites W2133064156 @default.
- W2620343734 cites W2133655297 @default.
- W2620343734 cites W2137698660 @default.
- W2620343734 cites W2142594520 @default.
- W2620343734 cites W2143731593 @default.
- W2620343734 cites W2144201925 @default.
- W2620343734 cites W2149232375 @default.
- W2620343734 cites W2150433660 @default.
- W2620343734 cites W2154892697 @default.
- W2620343734 cites W2156415043 @default.
- W2620343734 cites W2159896657 @default.
- W2620343734 cites W2160174030 @default.
- W2620343734 cites W2165144791 @default.
- W2620343734 cites W2171709048 @default.
- W2620343734 cites W2179341216 @default.
- W2620343734 cites W2293955632 @default.
- W2620343734 cites W2396645790 @default.
- W2620343734 cites W2401642881 @default.
- W2620343734 cites W2520496580 @default.
- W2620343734 cites W4241171398 @default.
- W2620343734 doi "https://doi.org/10.1038/ncomms15627" @default.
- W2620343734 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5460037" @default.
- W2620343734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28561023" @default.
- W2620343734 hasPublicationYear "2017" @default.
- W2620343734 type Work @default.
- W2620343734 sameAs 2620343734 @default.
- W2620343734 citedByCount "46" @default.
- W2620343734 countsByYear W26203437342017 @default.
- W2620343734 countsByYear W26203437342018 @default.
- W2620343734 countsByYear W26203437342019 @default.
- W2620343734 countsByYear W26203437342020 @default.
- W2620343734 countsByYear W26203437342021 @default.
- W2620343734 countsByYear W26203437342022 @default.
- W2620343734 countsByYear W26203437342023 @default.
- W2620343734 crossrefType "journal-article" @default.
- W2620343734 hasAuthorship W2620343734A5002674606 @default.
- W2620343734 hasAuthorship W2620343734A5021331386 @default.
- W2620343734 hasAuthorship W2620343734A5022927127 @default.
- W2620343734 hasAuthorship W2620343734A5040973657 @default.
- W2620343734 hasAuthorship W2620343734A5048548750 @default.
- W2620343734 hasAuthorship W2620343734A5055691289 @default.