Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620432821> ?p ?o ?g. }
- W2620432821 endingPage "1381" @default.
- W2620432821 startingPage "1370" @default.
- W2620432821 abstract "Underlying type 1 diabetes is a genetic aetiology dominated by the influence of specific HLA haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children with the DR4-DQ8 haplotype, exogenous factors, yet to be identified, are thought to trigger an autoimmune reaction against insulin, signalled by insulin autoantibodies as the first autoantibody to appear. In children with the DR3-DQ2 haplotype, the triggering reaction is primarily against GAD signalled by GAD autoantibodies (GADA) as the first-appearing autoantibody. The incidence rate of insulin autoantibodies as the first-appearing autoantibody peaks during the first years of life and declines thereafter. The incidence rate of GADA as the first-appearing autoantibody peaks later but does not decline. The first autoantibody may variably be followed, in an apparently non-HLA-associated pathogenesis, by a second, third or fourth autoantibody. Although not all persons with a single type of autoantibody progress to diabetes, the presence of multiple autoantibodies seems invariably to be followed by loss of functional beta cell mass and eventually by dysglycaemia and symptoms. Infiltration of mononuclear cells in and around the islets appears to be a late phenomenon appearing in the multiple-autoantibody-positive with dysglycaemia. As our understanding of the aetiology and pathogenesis of type 1 diabetes advances, the improved capability for early prediction should guide new strategies for the prevention of type 1 diabetes." @default.
- W2620432821 created "2017-06-05" @default.
- W2620432821 creator A5008841181 @default.
- W2620432821 creator A5013461948 @default.
- W2620432821 date "2017-05-26" @default.
- W2620432821 modified "2023-10-04" @default.
- W2620432821 title "Early prediction of autoimmune (type 1) diabetes" @default.
- W2620432821 cites W1484210663 @default.
- W2620432821 cites W1519521580 @default.
- W2620432821 cites W1522245135 @default.
- W2620432821 cites W1528955459 @default.
- W2620432821 cites W1547780927 @default.
- W2620432821 cites W1574138266 @default.
- W2620432821 cites W1593743891 @default.
- W2620432821 cites W1723085314 @default.
- W2620432821 cites W1913359344 @default.
- W2620432821 cites W1942296996 @default.
- W2620432821 cites W1945765931 @default.
- W2620432821 cites W1965253904 @default.
- W2620432821 cites W1967209395 @default.
- W2620432821 cites W1969080742 @default.
- W2620432821 cites W1974312087 @default.
- W2620432821 cites W1977565591 @default.
- W2620432821 cites W1982836364 @default.
- W2620432821 cites W1988519907 @default.
- W2620432821 cites W1990514655 @default.
- W2620432821 cites W1991541126 @default.
- W2620432821 cites W2000274287 @default.
- W2620432821 cites W2004256935 @default.
- W2620432821 cites W2011108094 @default.
- W2620432821 cites W2011488645 @default.
- W2620432821 cites W2011929207 @default.
- W2620432821 cites W2025405969 @default.
- W2620432821 cites W2025921292 @default.
- W2620432821 cites W2026758622 @default.
- W2620432821 cites W2028008706 @default.
- W2620432821 cites W2028473737 @default.
- W2620432821 cites W2028990915 @default.
- W2620432821 cites W2032448018 @default.
- W2620432821 cites W2034298939 @default.
- W2620432821 cites W2037427501 @default.
- W2620432821 cites W2038053863 @default.
- W2620432821 cites W2038585732 @default.
- W2620432821 cites W2047390985 @default.
- W2620432821 cites W2048871785 @default.
- W2620432821 cites W2050044633 @default.
- W2620432821 cites W2050704260 @default.
- W2620432821 cites W2051883261 @default.
- W2620432821 cites W2052235660 @default.
- W2620432821 cites W2055463878 @default.
- W2620432821 cites W2056224850 @default.
- W2620432821 cites W2057474270 @default.
- W2620432821 cites W2059471307 @default.
- W2620432821 cites W2062564128 @default.
- W2620432821 cites W2063037320 @default.
- W2620432821 cites W2069819213 @default.
- W2620432821 cites W2076794464 @default.
- W2620432821 cites W2089934054 @default.
- W2620432821 cites W2091248527 @default.
- W2620432821 cites W2093326004 @default.
- W2620432821 cites W2093623454 @default.
- W2620432821 cites W2093989792 @default.
- W2620432821 cites W2095042565 @default.
- W2620432821 cites W2095256598 @default.
- W2620432821 cites W2096485353 @default.
- W2620432821 cites W2098899964 @default.
- W2620432821 cites W2099224853 @default.
- W2620432821 cites W2101070171 @default.
- W2620432821 cites W2102684459 @default.
- W2620432821 cites W2102733380 @default.
- W2620432821 cites W2103372961 @default.
- W2620432821 cites W2105271024 @default.
- W2620432821 cites W2107053825 @default.
- W2620432821 cites W2110123993 @default.
- W2620432821 cites W2110458118 @default.
- W2620432821 cites W2111562530 @default.
- W2620432821 cites W2111625815 @default.
- W2620432821 cites W2112530229 @default.
- W2620432821 cites W2112621258 @default.
- W2620432821 cites W2114521068 @default.
- W2620432821 cites W2115209313 @default.
- W2620432821 cites W2117060078 @default.
- W2620432821 cites W2118878703 @default.
- W2620432821 cites W2119249252 @default.
- W2620432821 cites W2119813462 @default.
- W2620432821 cites W2120452309 @default.
- W2620432821 cites W2121595329 @default.
- W2620432821 cites W2121669859 @default.
- W2620432821 cites W2123367066 @default.
- W2620432821 cites W2123412381 @default.
- W2620432821 cites W2124400068 @default.
- W2620432821 cites W2126510876 @default.
- W2620432821 cites W2126597885 @default.
- W2620432821 cites W2129387684 @default.
- W2620432821 cites W2130552423 @default.
- W2620432821 cites W2131691281 @default.
- W2620432821 cites W2133787144 @default.
- W2620432821 cites W2134391999 @default.