FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620448002> ?p ?o ?g. }

• W2620448002 endingPage "14" @default.
• W2620448002 startingPage "8" @default.
• W2620448002 abstract "Substantial epidemiological evidence supports the involvement of the Epstein–Barr virus (EBV) in multiple sclerosis (MS). Mechanisms through which EBV may increase MS risk are reviewed here. Most individuals contract EBV in early childhood yet only develop MS in early adulthood, by which time EBV has been latent for decades. When latent, EBV is confined to a minute subset of memory B cells: about 1000 cells in peripheral blood and 500,000 cells in the lymphoid system, mainly in the mouth. Reactivation of EBV in the central nervous system (CNS) has been proposed as a cause of MS. Alternatively, EBV may enable the recognition of “forbidden” antigens by memory B cells through its presence in this leukocyte type, as first proposed by Pender. Though the requirement for B cells in MS supports both hypotheses, EBV has not been consistently found in MS lesions, as would be expected. EBV episome replication during B cell division is now known to be inefficient, resulting in some descendant B cells becoming EBV-free after a few dozen divisions. EBV-free memory B cells in the CNS may thus have descended from a memory B cell which matured while containing EBV episomes, enabling its B cell receptor to recognize “forbidden” MS-causing antigens in the CNS, even if EBV is absent from this site." @default.
• W2620448002 created "2017-06-05" @default.
• W2620448002 creator A5056990045 @default.
• W2620448002 creator A5061921669 @default.
• W2620448002 date "2017-08-01" @default.
• W2620448002 modified "2023-10-03" @default.
• W2620448002 title "Epstein–Barr virus and multiple sclerosis: Updating Pender's hypothesis" @default.
• W2620448002 cites W1726755462 @default.
• W2620448002 cites W1856318570 @default.
• W2620448002 cites W1947310368 @default.
• W2620448002 cites W1961808093 @default.
• W2620448002 cites W1963858099 @default.
• W2620448002 cites W1965608155 @default.
• W2620448002 cites W1978295230 @default.
• W2620448002 cites W1982686463 @default.
• W2620448002 cites W1989371523 @default.
• W2620448002 cites W1993741037 @default.
• W2620448002 cites W1994966944 @default.
• W2620448002 cites W1997708668 @default.
• W2620448002 cites W1998258994 @default.
• W2620448002 cites W2003374233 @default.
• W2620448002 cites W2004779843 @default.
• W2620448002 cites W2005213102 @default.
• W2620448002 cites W2017245132 @default.
• W2620448002 cites W2019447967 @default.
• W2620448002 cites W2021310559 @default.
• W2620448002 cites W2037979244 @default.
• W2620448002 cites W2041983142 @default.
• W2620448002 cites W2048303046 @default.
• W2620448002 cites W2050064956 @default.
• W2620448002 cites W2050437747 @default.
• W2620448002 cites W2058387782 @default.
• W2620448002 cites W2067433386 @default.
• W2620448002 cites W2068065940 @default.
• W2620448002 cites W2079053367 @default.
• W2620448002 cites W2081632246 @default.
• W2620448002 cites W2088341378 @default.
• W2620448002 cites W2090297349 @default.
• W2620448002 cites W2108088418 @default.
• W2620448002 cites W2108752110 @default.
• W2620448002 cites W2114832666 @default.
• W2620448002 cites W2124777756 @default.
• W2620448002 cites W2126139178 @default.
• W2620448002 cites W2126239854 @default.
• W2620448002 cites W2126284284 @default.
• W2620448002 cites W2127582098 @default.
• W2620448002 cites W2134956041 @default.
• W2620448002 cites W2139113477 @default.
• W2620448002 cites W2148563799 @default.
• W2620448002 cites W2160880134 @default.
• W2620448002 cites W2161105752 @default.
• W2620448002 cites W2165068901 @default.
• W2620448002 cites W2168911910 @default.
• W2620448002 cites W2171347293 @default.
• W2620448002 cites W2224589828 @default.
• W2620448002 cites W2321442574 @default.
• W2620448002 cites W2394763511 @default.
• W2620448002 cites W2461595816 @default.
• W2620448002 cites W4210309403 @default.
• W2620448002 cites W4233694737 @default.
• W2620448002 cites W775956452 @default.
• W2620448002 doi "https://doi.org/10.1016/j.msard.2017.05.009" @default.
• W2620448002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28755684" @default.
• W2620448002 hasPublicationYear "2017" @default.
• W2620448002 type Work @default.
• W2620448002 sameAs 2620448002 @default.
• W2620448002 citedByCount "42" @default.
• W2620448002 countsByYear W26204480022017 @default.
• W2620448002 countsByYear W26204480022018 @default.
• W2620448002 countsByYear W26204480022019 @default.
• W2620448002 countsByYear W26204480022020 @default.
• W2620448002 countsByYear W26204480022021 @default.
• W2620448002 countsByYear W26204480022022 @default.
• W2620448002 countsByYear W26204480022023 @default.
• W2620448002 crossrefType "journal-article" @default.
• W2620448002 hasAuthorship W2620448002A5056990045 @default.
• W2620448002 hasAuthorship W2620448002A5061921669 @default.
• W2620448002 hasBestOaLocation W26204480021 @default.
• W2620448002 hasConcept C147483822 @default.
• W2620448002 hasConcept C159047783 @default.
• W2620448002 hasConcept C159654299 @default.
• W2620448002 hasConcept C203014093 @default.
• W2620448002 hasConcept C2522874641 @default.
• W2620448002 hasConcept C2778453870 @default.
• W2620448002 hasConcept C2778529815 @default.
• W2620448002 hasConcept C2779359726 @default.
• W2620448002 hasConcept C2780640218 @default.
• W2620448002 hasConcept C2781375147 @default.
• W2620448002 hasConcept C71924100 @default.
• W2620448002 hasConcept C86803240 @default.
• W2620448002 hasConceptScore W2620448002C147483822 @default.
• W2620448002 hasConceptScore W2620448002C159047783 @default.
• W2620448002 hasConceptScore W2620448002C159654299 @default.
• W2620448002 hasConceptScore W2620448002C203014093 @default.
• W2620448002 hasConceptScore W2620448002C2522874641 @default.
• W2620448002 hasConceptScore W2620448002C2778453870 @default.
• W2620448002 hasConceptScore W2620448002C2778529815 @default.
• W2620448002 hasConceptScore W2620448002C2779359726 @default.

• next