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- W2620452546 abstract "Aim KIRs are NK cell surface proteins that play an important role modulating the cytotoxicity of these cells. The balance of activating and inhibitory signals interactions results in induction or inhibition of NK-mediated target cell lysis. KIR genes can be present or absent into individual repertory and thus exhibit different combinations of 14 functional genes (8 encoding inhibitory receptors; 6 genes encoding activator receptors) and 2 pseudogenes setting genotypes. KIR frequencies and genotypes data may contribute to a better-understanding of evolution and mechanisms involved in NK-mediated cytotoxicity. Methods KIR genotyping was carried out through KIR SSO Genotyping Test (One Lambda Inc.) and PCR-SSOP of 93 Caucasian unrelated kidney donors from HUEC Hospital (Parana - Brazil). Results and analysis were produced with HLA Fusion ® (One Lambda Inc.) software package. We compare KIR gene carrier frequency (rxc Contingency Tables) from our sample with frequency data from other Caucasian populations (Brazilian and European) described in the literature. Results Gene frequencies found in the present study were: KIR3DL3(1.00), KIR2DS2(0.53), KIR2DL2(0.45), KIR2DL3(0.90), KIR2DP1(1.00), KIR2DL1(0.99), KIR3DP1(1.00), KIR2DL4(1.00), KIR3DL1(0.94), KIR3DS1(0.41), KIR2DL5(0.55), KIR2DS3(0.37), KIR2DS5(0.22), KIR2DS1(0.41), KIR2DS4(0.82) and KIR3DL2(1.00). These frequencies are very similar to frequencies found in another Brazilian population from a different region, as well as for the French and British Caucasian populations. Conclusions Gene frequencies found in the present study were: KIR3DL3(1.00), KIR2DS2(0.53), KIR2DL2(0.45), KIR2DL3(0.90), KIR2DP1(1.00), KIR2DL1(0.99), KIR3DP1(1.00), KIR2DL4(1.00), KIR3DL1(0.94), KIR3DS1(0.41), KIR2DL5(0.55), KIR2DS3(0.37), KIR2DS5(0.22), KIR2DS1(0.41), KIR2DS4(0.82) and KIR3DL2(1.00). These frequencies are very similar to frequencies found in another Brazilian population from a different region, as well as for the French and British Caucasian populations." @default.
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- W2620452546 date "2012-10-01" @default.
- W2620452546 modified "2023-09-27" @default.
- W2620452546 title "100-P" @default.
- W2620452546 doi "https://doi.org/10.1016/j.humimm.2012.07.226" @default.
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