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- W2620473448 abstract "The past decade has seen a rapid proliferation in the number and types of systemic therapies available for renal cell carcinoma. However, surgery remains an integral component of the therapeutic armamentarium for advanced and metastatic kidney cancer. Cytoreductive surgery followed by adjuvant cytokine-based immunotherapy (predominantly high-dose interleukin 2) has largely given way to systemic-targeted therapies. Metastasectomy also has a role in carefully selected patients. Additionally, neoadjuvant systemic therapy may increase the feasibility of resecting the primary tumor, which may be beneficial for patients with locally advanced or metastatic disease. Several prospective trials examining the role of adjuvant therapy are underway. Lastly, the first immune checkpoint inhibitor was approved for metastatic renal cell carcinoma (mRCC) in 2015, providing a new treatment mechanism and new opportunities for combining systemic therapy with surgery. This review discusses current and historical literature regarding the surgical management of patients with advanced and mRCC and explores approaches for optimizing patient selection." @default.
- W2620473448 created "2017-06-05" @default.
- W2620473448 creator A5009060794 @default.
- W2620473448 creator A5026037697 @default.
- W2620473448 creator A5044026355 @default.
- W2620473448 creator A5049643340 @default.
- W2620473448 creator A5056022089 @default.
- W2620473448 creator A5071773606 @default.
- W2620473448 creator A5073047840 @default.
- W2620473448 date "2017-05-31" @default.
- W2620473448 modified "2023-10-04" @default.
- W2620473448 title "Surgical Management of Advanced and Metastatic Renal Cell Carcinoma: A Multidisciplinary Approach" @default.
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