FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620478605> ?p ?o ?g. }

• W2620478605 endingPage "2257" @default.
• W2620478605 startingPage "2245" @default.
• W2620478605 abstract "Cervical cancer is one of the most common malignant tumors in women all over the world. The exact mechanism of occurrence and development of cervical cancer has not been fully elucidated. CD38 is a type II transmembrane glycoprotein, which was found to mediate diverse activities, including signal transduction, cell adhesion, and cyclic ADP-ribose synthesis. Here, we reported that CD38 promoted cell proliferation and inhibited cell apoptosis in cervical cancer cells by affecting the mitochondria functions. We established stable cervical cancer cell lines with CD38 over-expressed. CCK8 assay and colony formation assay indicated that CD38 promoted cervical cancer cell proliferation. Nude mouse tumorigenicity assay showed that CD38 significantly promotes tumor growth in vivo. CD38 also induced S phase accumulation in cell cycle analysis and suppressed cell apoptosis in cervical cancer cells. Meanwhile, flow cytometry analysis of mitochondria functions suggested that CD38 decreased intracellular Ca2+ levels in cervical cancer cells and CD38 was involved in down-regulation of ROS levels and prevented mitochondrial apoptosis in cervical cancer cells. The percentage of cells with loss of mitochondrial membrane potential (Δψm) in CD38-overexpressed cervical cancer cells was less than control groups. Furthermore, we found an up-regulation of MDM2, cyclinA1, CDK4, cyclinD1, NF-kB P65, c-rel, and a downregulation of P53, P21, and P38 by Western blot analysis. These results indicated that CD38 enhanced the proliferation and inhibited the apoptosis of cervical cancer cells by affecting the mitochondria functions." @default.
• W2620478605 created "2017-06-05" @default.
• W2620478605 creator A5003324129 @default.
• W2620478605 creator A5004116656 @default.
• W2620478605 creator A5011130387 @default.
• W2620478605 creator A5013796517 @default.
• W2620478605 creator A5024766789 @default.
• W2620478605 creator A5026091430 @default.
• W2620478605 creator A5032162374 @default.
• W2620478605 creator A5036903229 @default.
• W2620478605 creator A5039627537 @default.
• W2620478605 creator A5047690802 @default.
• W2620478605 creator A5048211064 @default.
• W2620478605 creator A5051334432 @default.
• W2620478605 creator A5056975844 @default.
• W2620478605 creator A5063709934 @default.
• W2620478605 creator A5064417499 @default.
• W2620478605 creator A5065237130 @default.
• W2620478605 creator A5074028169 @default.
• W2620478605 creator A5081985857 @default.
• W2620478605 creator A5088617130 @default.
• W2620478605 creator A5090350458 @default.
• W2620478605 date "2017-06-30" @default.
• W2620478605 modified "2023-10-17" @default.
• W2620478605 title "CD38 enhances the proliferation and inhibits the apoptosis of cervical cancer cells by affecting the mitochondria functions" @default.
• W2620478605 cites W1575893280 @default.
• W2620478605 cites W1831100490 @default.
• W2620478605 cites W1957451152 @default.
• W2620478605 cites W1972571361 @default.
• W2620478605 cites W1977231617 @default.
• W2620478605 cites W1987292751 @default.
• W2620478605 cites W1990141012 @default.
• W2620478605 cites W2010658521 @default.
• W2620478605 cites W2012174792 @default.
• W2620478605 cites W2017099154 @default.
• W2620478605 cites W2025886777 @default.
• W2620478605 cites W2032025068 @default.
• W2620478605 cites W2038776315 @default.
• W2620478605 cites W2048312405 @default.
• W2620478605 cites W2049186181 @default.
• W2620478605 cites W2056344573 @default.
• W2620478605 cites W2061309593 @default.
• W2620478605 cites W2066447633 @default.
• W2620478605 cites W2072259475 @default.
• W2620478605 cites W2072356438 @default.
• W2620478605 cites W2082763359 @default.
• W2620478605 cites W2089665062 @default.
• W2620478605 cites W2106787323 @default.
• W2620478605 cites W2130302977 @default.
• W2620478605 cites W2133119201 @default.
• W2620478605 cites W2144299083 @default.
• W2620478605 cites W2149649923 @default.
• W2620478605 cites W2150166921 @default.
• W2620478605 cites W2164178354 @default.
• W2620478605 cites W2169627739 @default.
• W2620478605 cites W2193132386 @default.
• W2620478605 cites W2257937472 @default.
• W2620478605 cites W2272954896 @default.
• W2620478605 cites W2272984102 @default.
• W2620478605 cites W2309255581 @default.
• W2620478605 cites W2316911260 @default.
• W2620478605 cites W2325086434 @default.
• W2620478605 cites W2335496216 @default.
• W2620478605 cites W2337946946 @default.
• W2620478605 cites W2346980934 @default.
• W2620478605 cites W2367271341 @default.
• W2620478605 cites W2498411827 @default.
• W2620478605 cites W2508228262 @default.
• W2620478605 cites W2552484355 @default.
• W2620478605 doi "https://doi.org/10.1002/mc.22677" @default.
• W2620478605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28544069" @default.
• W2620478605 hasPublicationYear "2017" @default.
• W2620478605 type Work @default.
• W2620478605 sameAs 2620478605 @default.
• W2620478605 citedByCount "23" @default.
• W2620478605 countsByYear W26204786052018 @default.
• W2620478605 countsByYear W26204786052019 @default.
• W2620478605 countsByYear W26204786052020 @default.
• W2620478605 countsByYear W26204786052021 @default.
• W2620478605 countsByYear W26204786052022 @default.
• W2620478605 countsByYear W26204786052023 @default.
• W2620478605 crossrefType "journal-article" @default.
• W2620478605 hasAuthorship W2620478605A5003324129 @default.
• W2620478605 hasAuthorship W2620478605A5004116656 @default.
• W2620478605 hasAuthorship W2620478605A5011130387 @default.
• W2620478605 hasAuthorship W2620478605A5013796517 @default.
• W2620478605 hasAuthorship W2620478605A5024766789 @default.
• W2620478605 hasAuthorship W2620478605A5026091430 @default.
• W2620478605 hasAuthorship W2620478605A5032162374 @default.
• W2620478605 hasAuthorship W2620478605A5036903229 @default.
• W2620478605 hasAuthorship W2620478605A5039627537 @default.
• W2620478605 hasAuthorship W2620478605A5047690802 @default.
• W2620478605 hasAuthorship W2620478605A5048211064 @default.
• W2620478605 hasAuthorship W2620478605A5051334432 @default.
• W2620478605 hasAuthorship W2620478605A5056975844 @default.
• W2620478605 hasAuthorship W2620478605A5063709934 @default.
• W2620478605 hasAuthorship W2620478605A5064417499 @default.
• W2620478605 hasAuthorship W2620478605A5065237130 @default.

• next