FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620533072> ?p ?o ?g. }

• W2620533072 endingPage "1255" @default.
• W2620533072 startingPage "1245" @default.
• W2620533072 abstract "Long noncoding RNAs (lncRNAs), a new class of functional regulators involved in human tumorigenesis, have been attracting the increasing attention of researchers. The lncRNA colorectal neoplasia differentially expressed (CRNDE) gene, transcribed from chromosome 16 on the strand opposite the adjacent IRX5 gene, was originally found to be increased in CRC and was reported to be abnormally expressed in many cancers. However, its potential role and the molecular mechanism underlying the radioresistant phenotype formation of lung adenocarcinoma (LAD) remain unclear. In our present study, we identified that CRNDE was significantly upregulated in LAD tissue and radioresistant LAD cell lines. A high level of CRNDE expression was significantly correlated with poor differentiation, TNM stage, lymph node metastasis, radiotherapy response, and a significantly shorter overall survival. Gain- and loss-of-function tests revealed that CRNDE could influence the radiosensitivity of LAD cells by affecting the G 1 /S transition and causing apoptosis of LAD cells in vitro. Additionally, the mechanistic investigations showed that CRNDE could interact with PRC2 and recruit its core component EZH2 to p21 (CDKN1A) promoter regions and repress its transcription. Furthermore, rescue experiments were performed to confirm that CRNDE oncogenic function was partly through regulating p21. In conclusion, our data suggest that CRNDE may function as an oncogene by modulating p21, finally contributing to the radioresistant phenotype formation of LAD cells." @default.
• W2620533072 created "2017-06-05" @default.
• W2620533072 creator A5014510012 @default.
• W2620533072 creator A5018028379 @default.
• W2620533072 creator A5038562185 @default.
• W2620533072 creator A5050140916 @default.
• W2620533072 creator A5062136118 @default.
• W2620533072 creator A5077423550 @default.
• W2620533072 creator A5080733133 @default.
• W2620533072 creator A5088678385 @default.
• W2620533072 date "2018-09-14" @default.
• W2620533072 modified "2023-10-03" @default.
• W2620533072 title "Long Noncoding RNA CRNDE/PRC2 Participated in the Radiotherapy Resistance of Human Lung Adenocarcinoma Through Targeting p21 Expression" @default.
• W2620533072 cites W1571858136 @default.
• W2620533072 cites W1841269840 @default.
• W2620533072 cites W1981177991 @default.
• W2620533072 cites W1997203401 @default.
• W2620533072 cites W2060572930 @default.
• W2620533072 cites W2087377443 @default.
• W2620533072 cites W2134033103 @default.
• W2620533072 cites W2139709116 @default.
• W2620533072 cites W2144137532 @default.
• W2620533072 cites W2159903328 @default.
• W2620533072 cites W2191128990 @default.
• W2620533072 cites W2224645194 @default.
• W2620533072 cites W2270381642 @default.
• W2620533072 cites W2317325065 @default.
• W2620533072 cites W2343471288 @default.
• W2620533072 cites W2346098055 @default.
• W2620533072 cites W2488845020 @default.
• W2620533072 cites W2511592073 @default.
• W2620533072 cites W2518664370 @default.
• W2620533072 cites W2521827132 @default.
• W2620533072 cites W2551058041 @default.
• W2620533072 cites W2551580107 @default.
• W2620533072 cites W2555885116 @default.
• W2620533072 cites W2560793024 @default.
• W2620533072 cites W2560993675 @default.
• W2620533072 cites W2580805767 @default.
• W2620533072 cites W2582886239 @default.
• W2620533072 cites W2584951719 @default.
• W2620533072 cites W2585295293 @default.
• W2620533072 cites W2586906146 @default.
• W2620533072 cites W2586972673 @default.
• W2620533072 cites W2590266658 @default.
• W2620533072 cites W2590513734 @default.
• W2620533072 cites W2000393788 @default.
• W2620533072 doi "https://doi.org/10.3727/096504017x14944585873668" @default.
• W2620533072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7844700" @default.
• W2620533072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28550688" @default.
• W2620533072 hasPublicationYear "2018" @default.
• W2620533072 type Work @default.
• W2620533072 sameAs 2620533072 @default.
• W2620533072 citedByCount "47" @default.
• W2620533072 countsByYear W26205330722018 @default.
• W2620533072 countsByYear W26205330722019 @default.
• W2620533072 countsByYear W26205330722020 @default.
• W2620533072 countsByYear W26205330722021 @default.
• W2620533072 countsByYear W26205330722022 @default.
• W2620533072 countsByYear W26205330722023 @default.
• W2620533072 crossrefType "journal-article" @default.
• W2620533072 hasAuthorship W2620533072A5014510012 @default.
• W2620533072 hasAuthorship W2620533072A5018028379 @default.
• W2620533072 hasAuthorship W2620533072A5038562185 @default.
• W2620533072 hasAuthorship W2620533072A5050140916 @default.
• W2620533072 hasAuthorship W2620533072A5062136118 @default.
• W2620533072 hasAuthorship W2620533072A5077423550 @default.
• W2620533072 hasAuthorship W2620533072A5080733133 @default.
• W2620533072 hasAuthorship W2620533072A5088678385 @default.
• W2620533072 hasBestOaLocation W26205330721 @default.
• W2620533072 hasConcept C104317684 @default.
• W2620533072 hasConcept C121608353 @default.
• W2620533072 hasConcept C126322002 @default.
• W2620533072 hasConcept C127561419 @default.
• W2620533072 hasConcept C127716648 @default.
• W2620533072 hasConcept C206684579 @default.
• W2620533072 hasConcept C2777394393 @default.
• W2620533072 hasConcept C2781018059 @default.
• W2620533072 hasConcept C2781182431 @default.
• W2620533072 hasConcept C29537977 @default.
• W2620533072 hasConcept C502942594 @default.
• W2620533072 hasConcept C509974204 @default.
• W2620533072 hasConcept C54355233 @default.
• W2620533072 hasConcept C555283112 @default.
• W2620533072 hasConcept C58962609 @default.
• W2620533072 hasConcept C62203573 @default.
• W2620533072 hasConcept C71924100 @default.
• W2620533072 hasConcept C81885089 @default.
• W2620533072 hasConcept C86803240 @default.
• W2620533072 hasConceptScore W2620533072C104317684 @default.
• W2620533072 hasConceptScore W2620533072C121608353 @default.
• W2620533072 hasConceptScore W2620533072C126322002 @default.
• W2620533072 hasConceptScore W2620533072C127561419 @default.
• W2620533072 hasConceptScore W2620533072C127716648 @default.
• W2620533072 hasConceptScore W2620533072C206684579 @default.
• W2620533072 hasConceptScore W2620533072C2777394393 @default.
• W2620533072 hasConceptScore W2620533072C2781018059 @default.
• W2620533072 hasConceptScore W2620533072C2781182431 @default.

• next