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• W2620542945 startingPage "1593" @default.
• W2620542945 abstract "Interference from endogenous signaling enzymes represents a major hurdle for building orthogonal signaling cascades inside cells, particularly among closely related isoforms within an enzyme family. Here, we employed a genetically encoded chemical decaging strategy to build orthogonally activated kinase isoforms, with the endogenous counterparts temporally disabled by an extracellularly delivered bacterial effector. This approach eliminated any potential interference from other kinase isoforms as well as endogenous kinases, which allowed the specific, gain-of-function report of mitogen-activated protein kinase kinase 1 (MEK1) activity as opposed to MEK2 with high temporal resolution. Our study dissected the distinct enzymatic activity, feedback regulation and signal outputs between these closely related kinase isoforms." @default.
• W2620542945 created "2017-06-05" @default.
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• W2620542945 date "2017-07-05" @default.
• W2620542945 modified "2023-09-24" @default.
• W2620542945 title "Dissection of Kinase Isoforms through Orthogonal and Chemical Inducible Signaling Cascades" @default.
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• W2620542945 doi "https://doi.org/10.1002/cbic.201700255" @default.
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