Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620592862> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2620592862 endingPage "88" @default.
- W2620592862 startingPage "79" @default.
- W2620592862 abstract "The early bactericidal activity (EBA) of an antituberculosis agent is the daily decline in log10 colony forming units of M tuberculosis per ml of sputum during the first two days of treatment with the agent. It reflects the capacity of an agent to kill the actively metabolising organisms in tuberculosis lung cavities. It offers a relatively cheap means to evaluate the antituberculosis activity of an agent in a small group of patients within a matter of months. This article summarizes the authors’ experience in seven published EBA studies and identifies sources of variation in the procedure. The patients who participated in these studies had a mean age of 33 years, a mean weight of 50 kg and there was extensive or massive involvement of the lungs in 55% of patients. The highest EBA values (0,50-0,66) were found in groups of patients receiving isoniazid and the lowest values (0,05 and 0,09 respectively), in patients receiving the aminoglycosides amikacin and paromomycin in a dose of 15 mg/kg body weight. The variation in EBA in 248 patients was 0,0312 and the variation ascribable to the process of sputum production and collection was 0,0233. This implies that the different aspects of sputum production and collection involved in obtaining a representative sputum sample are responsible for most of the variation in EBA results. The selection of patients for inclusion in EBA studies and their ability to co-operate in producing a representative sputum specimen are of critical importance in the successful completion of EBA studies." @default.
- W2620592862 created "2017-06-09" @default.
- W2620592862 creator A5000540181 @default.
- W2620592862 creator A5025239159 @default.
- W2620592862 creator A5057955385 @default.
- W2620592862 creator A5080320442 @default.
- W2620592862 creator A5081514737 @default.
- W2620592862 creator A5085979264 @default.
- W2620592862 creator A5090582190 @default.
- W2620592862 creator A5091579378 @default.
- W2620592862 date "2003-09-26" @default.
- W2620592862 modified "2023-09-28" @default.
- W2620592862 title "A review of the determination of the early bactericidal activity of various antituberculosis agents" @default.
- W2620592862 cites W1986822335 @default.
- W2620592862 cites W2011863437 @default.
- W2620592862 cites W2027333630 @default.
- W2620592862 cites W2034152946 @default.
- W2620592862 cites W2038826236 @default.
- W2620592862 cites W2065376976 @default.
- W2620592862 cites W2070278937 @default.
- W2620592862 cites W2114698696 @default.
- W2620592862 cites W2151757899 @default.
- W2620592862 cites W2155336089 @default.
- W2620592862 cites W2398871980 @default.
- W2620592862 cites W1983235507 @default.
- W2620592862 doi "https://doi.org/10.4102/satnt.v22i2/3.215" @default.
- W2620592862 hasPublicationYear "2003" @default.
- W2620592862 type Work @default.
- W2620592862 sameAs 2620592862 @default.
- W2620592862 citedByCount "0" @default.
- W2620592862 crossrefType "journal-article" @default.
- W2620592862 hasAuthorship W2620592862A5000540181 @default.
- W2620592862 hasAuthorship W2620592862A5025239159 @default.
- W2620592862 hasAuthorship W2620592862A5057955385 @default.
- W2620592862 hasAuthorship W2620592862A5080320442 @default.
- W2620592862 hasAuthorship W2620592862A5081514737 @default.
- W2620592862 hasAuthorship W2620592862A5085979264 @default.
- W2620592862 hasAuthorship W2620592862A5090582190 @default.
- W2620592862 hasAuthorship W2620592862A5091579378 @default.
- W2620592862 hasBestOaLocation W26205928621 @default.
- W2620592862 hasConcept C126322002 @default.
- W2620592862 hasConcept C142724271 @default.
- W2620592862 hasConcept C2776301714 @default.
- W2620592862 hasConcept C2776967927 @default.
- W2620592862 hasConcept C2777427914 @default.
- W2620592862 hasConcept C2781069245 @default.
- W2620592862 hasConcept C2908628106 @default.
- W2620592862 hasConcept C501593827 @default.
- W2620592862 hasConcept C71924100 @default.
- W2620592862 hasConcept C86803240 @default.
- W2620592862 hasConcept C89423630 @default.
- W2620592862 hasConcept C98274493 @default.
- W2620592862 hasConceptScore W2620592862C126322002 @default.
- W2620592862 hasConceptScore W2620592862C142724271 @default.
- W2620592862 hasConceptScore W2620592862C2776301714 @default.
- W2620592862 hasConceptScore W2620592862C2776967927 @default.
- W2620592862 hasConceptScore W2620592862C2777427914 @default.
- W2620592862 hasConceptScore W2620592862C2781069245 @default.
- W2620592862 hasConceptScore W2620592862C2908628106 @default.
- W2620592862 hasConceptScore W2620592862C501593827 @default.
- W2620592862 hasConceptScore W2620592862C71924100 @default.
- W2620592862 hasConceptScore W2620592862C86803240 @default.
- W2620592862 hasConceptScore W2620592862C89423630 @default.
- W2620592862 hasConceptScore W2620592862C98274493 @default.
- W2620592862 hasIssue "2/3" @default.
- W2620592862 hasLocation W26205928621 @default.
- W2620592862 hasOpenAccess W2620592862 @default.
- W2620592862 hasPrimaryLocation W26205928621 @default.
- W2620592862 hasRelatedWork W1698118555 @default.
- W2620592862 hasRelatedWork W2051361053 @default.
- W2620592862 hasRelatedWork W2096245909 @default.
- W2620592862 hasRelatedWork W2354515935 @default.
- W2620592862 hasRelatedWork W2368470580 @default.
- W2620592862 hasRelatedWork W2369623725 @default.
- W2620592862 hasRelatedWork W2390045243 @default.
- W2620592862 hasRelatedWork W2402006497 @default.
- W2620592862 hasRelatedWork W3165151283 @default.
- W2620592862 hasRelatedWork W2182590035 @default.
- W2620592862 hasVolume "22" @default.
- W2620592862 isParatext "false" @default.
- W2620592862 isRetracted "false" @default.
- W2620592862 magId "2620592862" @default.
- W2620592862 workType "article" @default.