FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620620967> ?p ?o ?g. }

• W2620620967 endingPage "1999" @default.
• W2620620967 startingPage "1986" @default.
• W2620620967 abstract "Parkinson's disease is the second most common neurodegenerative disease. It is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. 1-Methyl-4-phenylpyridinium (MPP+) is a dopaminergic neuronal toxin that is widely used in constructing Parkinson's disease models in vitro. Low-intensity pulsed ultrasound (LIPUS) is a non-invasive therapeutic approach that has neuromodulation and neuroprotective effects in the central neural system; however, whether LIPUS can provide protection for dopaminergic neurons against MPP+-induced neurocytotoxicity remains unknown. In this study, we found that pre-treatment with LIPUS (1 MHz, 50 mW/cm2, 20% duty cycle and 100-Hz pulse repetition frequency, 10 min) inhibited MPP+-induced neurotoxicity and mitochondrial dysfunction in PC12 cells. LIPUS decreased MPP+-induced oxidative stress by modulating antioxidant proteins, including thioredoxin-1 and heme oxygenase-1, and prevented neurocytotoxicity via the phosphoinositide 3-kinase (PI3K)-Akt and ERK1/2 pathways. Furthermore, these beneficial effects were attributed to the activation of K2P channels and stretch-activated ion channels by LIPUS. These data indicate that LIPUS protects neuronal cells from MPP+-induced cell death through the K2P channel- and stretch-activated ion channel-mediated downstream pathways. The data also suggest that LIPUS could be a promising therapeutic method in halting or retarding the degeneration of dopaminergic neurons in Parkinson's disease in a non-invasive manner." @default.
• W2620620967 created "2017-06-09" @default.
• W2620620967 creator A5003928699 @default.
• W2620620967 creator A5007688000 @default.
• W2620620967 creator A5029700987 @default.
• W2620620967 creator A5050925013 @default.
• W2620620967 creator A5052654593 @default.
• W2620620967 creator A5056716223 @default.
• W2620620967 date "2017-09-01" @default.
• W2620620967 modified "2023-10-17" @default.
• W2620620967 title "Neuroprotective Effect of Low-Intensity Pulsed Ultrasound Against MPP + -Induced Neurotoxicity in PC12 Cells: Involvement of K2P Channels and Stretch-Activated Ion Channels" @default.
• W2620620967 cites W1547122167 @default.
• W2620620967 cites W1569732784 @default.
• W2620620967 cites W1587726204 @default.
• W2620620967 cites W1754605913 @default.
• W2620620967 cites W1967165894 @default.
• W2620620967 cites W1968854074 @default.
• W2620620967 cites W1969268163 @default.
• W2620620967 cites W1970587959 @default.
• W2620620967 cites W1971155331 @default.
• W2620620967 cites W1973081785 @default.
• W2620620967 cites W1974212976 @default.
• W2620620967 cites W1977252372 @default.
• W2620620967 cites W1986439675 @default.
• W2620620967 cites W1991387227 @default.
• W2620620967 cites W1996472473 @default.
• W2620620967 cites W1997382573 @default.
• W2620620967 cites W2000512629 @default.
• W2620620967 cites W2000756556 @default.
• W2620620967 cites W2002212469 @default.
• W2620620967 cites W2007011945 @default.
• W2620620967 cites W2010287108 @default.
• W2620620967 cites W2014337155 @default.
• W2620620967 cites W2019019227 @default.
• W2620620967 cites W2019083403 @default.
• W2620620967 cites W2026849735 @default.
• W2620620967 cites W2027387545 @default.
• W2620620967 cites W2029793678 @default.
• W2620620967 cites W2031873367 @default.
• W2620620967 cites W2032466814 @default.
• W2620620967 cites W2037233527 @default.
• W2620620967 cites W2038557175 @default.
• W2620620967 cites W2041274415 @default.
• W2620620967 cites W2042263688 @default.
• W2620620967 cites W2048897966 @default.
• W2620620967 cites W2051887385 @default.
• W2620620967 cites W2054631938 @default.
• W2620620967 cites W2071571725 @default.
• W2620620967 cites W2074475472 @default.
• W2620620967 cites W2077260129 @default.
• W2620620967 cites W2079510855 @default.
• W2620620967 cites W2087877138 @default.
• W2620620967 cites W2088304415 @default.
• W2620620967 cites W2102491127 @default.
• W2620620967 cites W2104032880 @default.
• W2620620967 cites W2109628664 @default.
• W2620620967 cites W2112956889 @default.
• W2620620967 cites W2116056782 @default.
• W2620620967 cites W2124603205 @default.
• W2620620967 cites W2130356495 @default.
• W2620620967 cites W2150881749 @default.
• W2620620967 cites W2152165298 @default.
• W2620620967 cites W2153528954 @default.
• W2620620967 cites W2159144035 @default.
• W2620620967 cites W2162574319 @default.
• W2620620967 cites W2163111262 @default.
• W2620620967 cites W2164240080 @default.
• W2620620967 cites W2166196917 @default.
• W2620620967 cites W2271885288 @default.
• W2620620967 cites W2274959647 @default.
• W2620620967 cites W2325082853 @default.
• W2620620967 cites W2339456745 @default.
• W2620620967 cites W2340338776 @default.
• W2620620967 cites W2342931385 @default.
• W2620620967 cites W2416700092 @default.
• W2620620967 cites W2514073935 @default.
• W2620620967 cites W2518052674 @default.
• W2620620967 cites W62603772 @default.
• W2620620967 doi "https://doi.org/10.1016/j.ultrasmedbio.2017.04.020" @default.
• W2620620967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28583325" @default.
• W2620620967 hasPublicationYear "2017" @default.
• W2620620967 type Work @default.
• W2620620967 sameAs 2620620967 @default.
• W2620620967 citedByCount "28" @default.
• W2620620967 countsByYear W26206209672017 @default.
• W2620620967 countsByYear W26206209672019 @default.
• W2620620967 countsByYear W26206209672020 @default.
• W2620620967 countsByYear W26206209672021 @default.
• W2620620967 countsByYear W26206209672022 @default.
• W2620620967 countsByYear W26206209672023 @default.
• W2620620967 crossrefType "journal-article" @default.
• W2620620967 hasAuthorship W2620620967A5003928699 @default.
• W2620620967 hasAuthorship W2620620967A5007688000 @default.
• W2620620967 hasAuthorship W2620620967A5029700987 @default.
• W2620620967 hasAuthorship W2620620967A5050925013 @default.
• W2620620967 hasAuthorship W2620620967A5052654593 @default.
• W2620620967 hasAuthorship W2620620967A5056716223 @default.
• W2620620967 hasConcept C126322002 @default.

• next