Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620657091> ?p ?o ?g. }
- W2620657091 endingPage "259" @default.
- W2620657091 startingPage "251" @default.
- W2620657091 abstract "Several nuclear and nucleic acid-binding proteins were detected in the proteomic analyses of ciliary fractions from various organisms. Yet very little is known about the role of these proteins in ciliogenesis and ciliary signaling. In an attempt to characterize the role of these nuclear proteins, we identified a hypothetical protein from Chlamydomonas reinhardtii, CrRuvBL1, which is homologous to human DNA helicase, HsRuvBL1. CrRuvBL1 localizes to flagella and nucleus in vegetative Chlamydomonas cells. It accumulates in the nucleus specifically during initial stages of flagellar assembly and cell division indicating its role in these processes. Mammalian counterpart of this protein, HsRuvBL1, was found to be present at the basal bodies and in the primary cilium of quiescent Retinal Pigment Epithelial (RPE1) cells. In interphase cells, HsRuvBL1 is present at centrioles while the protein localizes on spindle fibers, spindle poles and midbodies, which are important structures formed during different phases of cell division. Depletion of HsRuvBL1 by using siRNAs leads to complete loss of primary cilia in RPE1 cells. Together these results suggest that nuclear proteins play an important role in ciliogenesis." @default.
- W2620657091 created "2017-06-09" @default.
- W2620657091 creator A5002400603 @default.
- W2620657091 creator A5009281753 @default.
- W2620657091 date "2017-06-15" @default.
- W2620657091 modified "2023-10-01" @default.
- W2620657091 title "Human DNA helicase, RuvBL1 and its <i>Chlamydomonas</i> homologue, CrRuvBL1 plays an important role in ciliogenesis" @default.
- W2620657091 cites W162961686 @default.
- W2620657091 cites W1842868555 @default.
- W2620657091 cites W1971060771 @default.
- W2620657091 cites W1979540894 @default.
- W2620657091 cites W1989187266 @default.
- W2620657091 cites W1991623275 @default.
- W2620657091 cites W1995362011 @default.
- W2620657091 cites W1999022290 @default.
- W2620657091 cites W2018075425 @default.
- W2620657091 cites W2023489445 @default.
- W2620657091 cites W2030939638 @default.
- W2620657091 cites W2039879202 @default.
- W2620657091 cites W2039956849 @default.
- W2620657091 cites W2040416423 @default.
- W2620657091 cites W2047596417 @default.
- W2620657091 cites W2047752494 @default.
- W2620657091 cites W2049876198 @default.
- W2620657091 cites W2054131393 @default.
- W2620657091 cites W2060970598 @default.
- W2620657091 cites W2065337493 @default.
- W2620657091 cites W2068666076 @default.
- W2620657091 cites W206957569 @default.
- W2620657091 cites W2071401245 @default.
- W2620657091 cites W2073521369 @default.
- W2620657091 cites W2074458710 @default.
- W2620657091 cites W2076018659 @default.
- W2620657091 cites W2083616180 @default.
- W2620657091 cites W2102358227 @default.
- W2620657091 cites W2109627636 @default.
- W2620657091 cites W2110283302 @default.
- W2620657091 cites W2115269983 @default.
- W2620657091 cites W2117860347 @default.
- W2620657091 cites W2126212740 @default.
- W2620657091 cites W2129394277 @default.
- W2620657091 cites W2131422895 @default.
- W2620657091 cites W2139199411 @default.
- W2620657091 cites W2143724861 @default.
- W2620657091 cites W2148151206 @default.
- W2620657091 cites W2149549102 @default.
- W2620657091 cites W2156190275 @default.
- W2620657091 cites W2158220085 @default.
- W2620657091 cites W2166977115 @default.
- W2620657091 cites W2167075028 @default.
- W2620657091 cites W389986128 @default.
- W2620657091 doi "https://doi.org/10.1002/cm.21377" @default.
- W2620657091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28574207" @default.
- W2620657091 hasPublicationYear "2017" @default.
- W2620657091 type Work @default.
- W2620657091 sameAs 2620657091 @default.
- W2620657091 citedByCount "7" @default.
- W2620657091 countsByYear W26206570912018 @default.
- W2620657091 countsByYear W26206570912019 @default.
- W2620657091 countsByYear W26206570912020 @default.
- W2620657091 countsByYear W26206570912021 @default.
- W2620657091 countsByYear W26206570912022 @default.
- W2620657091 countsByYear W26206570912023 @default.
- W2620657091 crossrefType "journal-article" @default.
- W2620657091 hasAuthorship W2620657091A5002400603 @default.
- W2620657091 hasAuthorship W2620657091A5009281753 @default.
- W2620657091 hasConcept C100094513 @default.
- W2620657091 hasConcept C104317684 @default.
- W2620657091 hasConcept C10447061 @default.
- W2620657091 hasConcept C115811362 @default.
- W2620657091 hasConcept C131151476 @default.
- W2620657091 hasConcept C143065580 @default.
- W2620657091 hasConcept C1491633281 @default.
- W2620657091 hasConcept C161223559 @default.
- W2620657091 hasConcept C195267511 @default.
- W2620657091 hasConcept C2776580309 @default.
- W2620657091 hasConcept C2777727519 @default.
- W2620657091 hasConcept C29512474 @default.
- W2620657091 hasConcept C29537977 @default.
- W2620657091 hasConcept C48342290 @default.
- W2620657091 hasConcept C54355233 @default.
- W2620657091 hasConcept C67705224 @default.
- W2620657091 hasConcept C86339819 @default.
- W2620657091 hasConcept C86803240 @default.
- W2620657091 hasConcept C93304396 @default.
- W2620657091 hasConcept C95444343 @default.
- W2620657091 hasConceptScore W2620657091C100094513 @default.
- W2620657091 hasConceptScore W2620657091C104317684 @default.
- W2620657091 hasConceptScore W2620657091C10447061 @default.
- W2620657091 hasConceptScore W2620657091C115811362 @default.
- W2620657091 hasConceptScore W2620657091C131151476 @default.
- W2620657091 hasConceptScore W2620657091C143065580 @default.
- W2620657091 hasConceptScore W2620657091C1491633281 @default.
- W2620657091 hasConceptScore W2620657091C161223559 @default.
- W2620657091 hasConceptScore W2620657091C195267511 @default.
- W2620657091 hasConceptScore W2620657091C2776580309 @default.
- W2620657091 hasConceptScore W2620657091C2777727519 @default.
- W2620657091 hasConceptScore W2620657091C29512474 @default.