Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620665280> ?p ?o ?g. }
- W2620665280 endingPage "36" @default.
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- W2620665280 abstract "Synthesis, inter-conversions and biological study of the dichloro bridged dicopper(II) compound [CuLCl]2 (1) and its two mononuclear derivatives [CuLCl(H2O)]·H2O (2) and [CuLCl(py)] (3) (HL=2-(2-pyridylmethyleneamino)benzenesulfonic acid) are described. The dimeric compound 1 collapses into monomers 2 and 3 in the presence of coordinating solvents, water and pyridine, respectively, and 1 is regenerated upon simple stirring of 2 or 3 in methanol. The reactions of 1 with neutral (present study) and charged (earlier studies) ligands result in monomeric and multimeric compounds, respectively, attesting that it is a versatile dicopper(II) precursor. The anticancer activity of these copper complexes (1-3) was screened against lung (A-549) and breast (MDA-MB-231) human cancer cell lines. The IC50 (half maximal inhibitory concentration) value for one (3) of the compounds suggests preferential cytotoxicity against breast cancer MDA-MB-231 cell line. Furthermore, the IC50 value obtained for complex 3 is found to be almost two-fold times cytotoxic than the standard drug cisplatin. In addition, the underlying possible mechanism of its apoptosis-inducing efficacy in MDA-MB-231 cells has been rationalized by using flow cytometry (FACS) and Hoechst 33342/propidium iodide (PI) fluorescence staining. The stimulation of apoptotic induction for complex 3 has further been affirmed by reactive oxygen species (ROS) generation and mitochondrial aggregations studies." @default.
- W2620665280 created "2017-06-09" @default.
- W2620665280 creator A5024366756 @default.
- W2620665280 creator A5043450815 @default.
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- W2620665280 creator A5077968687 @default.
- W2620665280 creator A5081571915 @default.
- W2620665280 creator A5089296810 @default.
- W2620665280 date "2017-09-01" @default.
- W2620665280 modified "2023-09-27" @default.
- W2620665280 title "Unfolding biological properties of a versatile dicopper(II) precursor and its two mononuclear copper(II) derivatives" @default.
- W2620665280 cites W1028554517 @default.
- W2620665280 cites W1566271574 @default.
- W2620665280 cites W1775731860 @default.
- W2620665280 cites W1827842832 @default.
- W2620665280 cites W1861752925 @default.
- W2620665280 cites W1942532282 @default.
- W2620665280 cites W1968786402 @default.
- W2620665280 cites W1974693247 @default.
- W2620665280 cites W1974980101 @default.
- W2620665280 cites W1975797915 @default.
- W2620665280 cites W1980251832 @default.
- W2620665280 cites W1981760301 @default.
- W2620665280 cites W1982768906 @default.
- W2620665280 cites W1982915980 @default.
- W2620665280 cites W1984883623 @default.
- W2620665280 cites W1985244701 @default.
- W2620665280 cites W1990170643 @default.
- W2620665280 cites W1990338414 @default.
- W2620665280 cites W1996050410 @default.
- W2620665280 cites W1997483215 @default.
- W2620665280 cites W2007558419 @default.
- W2620665280 cites W2008035601 @default.
- W2620665280 cites W2009840678 @default.
- W2620665280 cites W2010319251 @default.
- W2620665280 cites W2012108057 @default.
- W2620665280 cites W2019202902 @default.
- W2620665280 cites W2020462998 @default.
- W2620665280 cites W2021017189 @default.
- W2620665280 cites W2021388388 @default.
- W2620665280 cites W2021876367 @default.
- W2620665280 cites W2022938402 @default.
- W2620665280 cites W2024377974 @default.
- W2620665280 cites W2028099409 @default.
- W2620665280 cites W2039901816 @default.
- W2620665280 cites W2041869855 @default.
- W2620665280 cites W2042384583 @default.
- W2620665280 cites W2048168597 @default.
- W2620665280 cites W2049251015 @default.
- W2620665280 cites W2050569993 @default.
- W2620665280 cites W2051140363 @default.
- W2620665280 cites W2055404938 @default.
- W2620665280 cites W2056089554 @default.
- W2620665280 cites W2056480721 @default.
- W2620665280 cites W2064398928 @default.
- W2620665280 cites W2070711340 @default.
- W2620665280 cites W2076605211 @default.
- W2620665280 cites W2077716969 @default.
- W2620665280 cites W2078901790 @default.
- W2620665280 cites W2083323458 @default.
- W2620665280 cites W2084853179 @default.
- W2620665280 cites W2085917831 @default.
- W2620665280 cites W2086276590 @default.
- W2620665280 cites W2087434958 @default.
- W2620665280 cites W2088454672 @default.
- W2620665280 cites W2089570099 @default.
- W2620665280 cites W2090776165 @default.
- W2620665280 cites W2094421559 @default.
- W2620665280 cites W2107933961 @default.
- W2620665280 cites W2113999599 @default.
- W2620665280 cites W2114918609 @default.
- W2620665280 cites W2121649359 @default.
- W2620665280 cites W2125282969 @default.
- W2620665280 cites W2131518547 @default.
- W2620665280 cites W2132994053 @default.
- W2620665280 cites W2135357230 @default.
- W2620665280 cites W2142237620 @default.
- W2620665280 cites W2146580818 @default.
- W2620665280 cites W2157732685 @default.
- W2620665280 cites W2161339168 @default.
- W2620665280 cites W2164533153 @default.
- W2620665280 cites W2166133816 @default.
- W2620665280 cites W2170756410 @default.
- W2620665280 cites W2297044744 @default.
- W2620665280 cites W2314382662 @default.
- W2620665280 cites W2314466643 @default.
- W2620665280 cites W2320045037 @default.
- W2620665280 cites W2320131143 @default.
- W2620665280 cites W2322974138 @default.
- W2620665280 cites W2324129490 @default.
- W2620665280 cites W2328915394 @default.
- W2620665280 cites W2348262290 @default.
- W2620665280 cites W2411819276 @default.
- W2620665280 cites W2412574752 @default.
- W2620665280 cites W2417861969 @default.
- W2620665280 cites W2505211494 @default.
- W2620665280 cites W2507514980 @default.
- W2620665280 cites W2509783391 @default.