FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620672034> ?p ?o ?g. }

• W2620672034 endingPage "681" @default.
• W2620672034 startingPage "672" @default.
• W2620672034 abstract "microRNAs (miRNAs) play important roles in adipogenesis that is closely linked to obesity and energy homeostasis. Thus far, only a few miRNAs have been identified to regulate adipocyte development, arousing interest in the detailed function of miRNAs during adipogenesis. In this study, we found that the miR-26b expression showed an increasing trend during 3T3-L1 cells differentiation. To investigate the role of miR-26b in adipogenesis, the synthetic miR-26b agomirs and antagomirs were used to perform overexpression and knockdown experiment, respectively. Our data revealed that overexpression of miR-26b significantly accelerated the mRNA expression of the adipogenic markers, peroxisome proliferator-activated receptor gamma (PPARγ), fatty acid synthase (FAS), CCAAT/enhancer binding protein alpha (C/EBPα), and lipoprotein lipase, and the protein level of PPARγ and FAS. miR-26b overexpression also resulted in a significant increase in lipid accumulation. In contrast, inhibition of miR-26b expression decreased differentiation of 3T3-L1 cells. By target gene prediction and luciferase reporter assay, we demonstrated that miR-26b may directly bind to the 3′ UTR of phosphatase and tensin homolog (PTEN). Taken together, these results demonstrate that miR-26b might participate in regulating adipogenic differentiation in 3T3-L1 cells by inhibiting the PTEN expression, further highlighting the importance of miRNA in adipogenesis." @default.
• W2620672034 created "2017-06-09" @default.
• W2620672034 creator A5001048927 @default.
• W2620672034 creator A5005064985 @default.
• W2620672034 creator A5030260621 @default.
• W2620672034 creator A5037586182 @default.
• W2620672034 creator A5046061491 @default.
• W2620672034 creator A5069354293 @default.
• W2620672034 creator A5076199866 @default.
• W2620672034 creator A5087146398 @default.
• W2620672034 date "2017-08-01" @default.
• W2620672034 modified "2023-10-06" @default.
• W2620672034 title "miR-26b Promotes 3T3-L1 Adipocyte Differentiation Through Targeting <i>PTEN</i>" @default.
• W2620672034 cites W144423133 @default.
• W2620672034 cites W1557110977 @default.
• W2620672034 cites W1648301895 @default.
• W2620672034 cites W1892131812 @default.
• W2620672034 cites W1927710737 @default.
• W2620672034 cites W1973331693 @default.
• W2620672034 cites W1978281808 @default.
• W2620672034 cites W1978402873 @default.
• W2620672034 cites W1993551950 @default.
• W2620672034 cites W1997386949 @default.
• W2620672034 cites W1998038367 @default.
• W2620672034 cites W1998493448 @default.
• W2620672034 cites W2008977230 @default.
• W2620672034 cites W2010410145 @default.
• W2620672034 cites W2014946489 @default.
• W2620672034 cites W2018507242 @default.
• W2620672034 cites W2020331673 @default.
• W2620672034 cites W2024123645 @default.
• W2620672034 cites W2043129312 @default.
• W2620672034 cites W2045434733 @default.
• W2620672034 cites W2046930479 @default.
• W2620672034 cites W2047254315 @default.
• W2620672034 cites W2052609811 @default.
• W2620672034 cites W2052878956 @default.
• W2620672034 cites W2059511498 @default.
• W2620672034 cites W2067336382 @default.
• W2620672034 cites W2067521961 @default.
• W2620672034 cites W2067870508 @default.
• W2620672034 cites W2068427129 @default.
• W2620672034 cites W2077582389 @default.
• W2620672034 cites W2085952650 @default.
• W2620672034 cites W2085957571 @default.
• W2620672034 cites W2086752996 @default.
• W2620672034 cites W2088986234 @default.
• W2620672034 cites W2091042488 @default.
• W2620672034 cites W2093856697 @default.
• W2620672034 cites W2098285533 @default.
• W2620672034 cites W2133470303 @default.
• W2620672034 cites W2151258296 @default.
• W2620672034 cites W2157993486 @default.
• W2620672034 cites W2218893500 @default.
• W2620672034 cites W2320394539 @default.
• W2620672034 cites W2530624925 @default.
• W2620672034 doi "https://doi.org/10.1089/dna.2017.3712" @default.
• W2620672034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28570839" @default.
• W2620672034 hasPublicationYear "2017" @default.
• W2620672034 type Work @default.
• W2620672034 sameAs 2620672034 @default.
• W2620672034 citedByCount "32" @default.
• W2620672034 countsByYear W26206720342017 @default.
• W2620672034 countsByYear W26206720342018 @default.
• W2620672034 countsByYear W26206720342019 @default.
• W2620672034 countsByYear W26206720342020 @default.
• W2620672034 countsByYear W26206720342021 @default.
• W2620672034 countsByYear W26206720342022 @default.
• W2620672034 countsByYear W26206720342023 @default.
• W2620672034 crossrefType "journal-article" @default.
• W2620672034 hasAuthorship W2620672034A5001048927 @default.
• W2620672034 hasAuthorship W2620672034A5005064985 @default.
• W2620672034 hasAuthorship W2620672034A5030260621 @default.
• W2620672034 hasAuthorship W2620672034A5037586182 @default.
• W2620672034 hasAuthorship W2620672034A5046061491 @default.
• W2620672034 hasAuthorship W2620672034A5069354293 @default.
• W2620672034 hasAuthorship W2620672034A5076199866 @default.
• W2620672034 hasAuthorship W2620672034A5087146398 @default.
• W2620672034 hasConcept C104317684 @default.
• W2620672034 hasConcept C122927707 @default.
• W2620672034 hasConcept C134018914 @default.
• W2620672034 hasConcept C145059251 @default.
• W2620672034 hasConcept C171089720 @default.
• W2620672034 hasConcept C173396325 @default.
• W2620672034 hasConcept C2776175234 @default.
• W2620672034 hasConcept C2777609662 @default.
• W2620672034 hasConcept C2779549131 @default.
• W2620672034 hasConcept C4733338 @default.
• W2620672034 hasConcept C48289651 @default.
• W2620672034 hasConcept C55493867 @default.
• W2620672034 hasConcept C62478195 @default.
• W2620672034 hasConcept C86554907 @default.
• W2620672034 hasConcept C86803240 @default.
• W2620672034 hasConcept C95444343 @default.
• W2620672034 hasConceptScore W2620672034C104317684 @default.
• W2620672034 hasConceptScore W2620672034C122927707 @default.
• W2620672034 hasConceptScore W2620672034C134018914 @default.
• W2620672034 hasConceptScore W2620672034C145059251 @default.

• next