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• W2620768649 abstract "Abstract Recent studies have analyzed large scale data sets of gene expression to identify genes associated with inter-individual variation in phenotypes ranging from cancer sub-types to drug sensitivity, promising new avenues of research in personalized medicine. However, gene expression data alone is limited in its ability to reveal cis-regulatory mechanisms underlying phenotypic differences. In this study, we develop a new probabilistic model, called pGENMi, that integrates multi-omics data to investigate the transcriptional regulatory mechanisms underlying inter-individual variation of a specific phenotype – that of cell line response to cytotoxic treatment. In particular, pGENMi simultaneously analyzes genotype, DNA methylation, gene expression and transcription factor (TF)-DNA binding data, along with phenotypic measurements, to identify TFs regulating the phenotype. It does so by combining statistical information about expression quantitative trait loci (eQTLs) and expression-correlated methylation marks (eQTMs) located within TF binding sites, as well as observed correlations between gene expression and phenotype variation. Application of pGENMi to data from a panel of lymphoblastoid cell lines treated with 24 drugs, in conjunction with ENCODE TF ChIP data, yielded a number of known as well as novel TF-drug associations. Experimental validations by TF knock-down confirmed 41% of the predicted and tested associations, compared to a 12% confirmation rate of tested non-associations (controls). Extensive literature survey also corroborated 62% of the predicted associations above a stringent threshold. Moreover, associations predicted only when combining eQTL and eQTM data showed higher precision compared to an eQTL-only or eQTM-only analysis with the same method, further demonstrating the value of multi-omic integrative analysis." @default.
• W2620768649 created "2017-06-09" @default.
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• W2620768649 date "2017-06-02" @default.
• W2620768649 modified "2023-09-25" @default.
• W2620768649 title "Principled Multi-Omic Analysis Reveals Gene Regulatory Mechanisms Of Phenotype Variation" @default.
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• W2620768649 doi "https://doi.org/10.1101/145607" @default.
• W2620768649 hasPublicationYear "2017" @default.
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