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• W2620771163 abstract "A novel series of 3-ketolithocholic acid derivatives as well as estrone derivatives bearing a small ring for the conformational fixation of the side chain were synthesized by using a catalytic [2+2] cycloaddition and a ring-contraction rearrangement. The steroidal derivatives were evaluated for transcriptional activation of vitamin D receptor by luciferase reporter assays. Among them, two estrone derivatives showed a higher efficacy of the transactivation of vitamin D receptor than 3-ketolithocholic acid, and the small ring moieties were found to be important for the efficacy." @default.
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• W2620771163 date "2017-08-01" @default.
• W2620771163 modified "2023-09-23" @default.
• W2620771163 title "Synthesis and biological evaluation of steroidal derivatives bearing a small ring as vitamin D receptor agonists" @default.
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• W2620771163 doi "https://doi.org/10.1016/j.bmcl.2017.05.089" @default.
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