Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620791330> ?p ?o ?g. }
- W2620791330 endingPage "323" @default.
- W2620791330 startingPage "313" @default.
- W2620791330 abstract "microRNAs (miRNAs) have wide-ranging effects on large-scale gene regulation. As such, they play a vital role in dictating normal development, and their aberrant expression has been implicated in cancer. There has been a large body of research on the role of miRNAs in medulloblastoma, the most common malignant brain tumor of childhood. The identification of the 4 molecular subgroups with distinct biological, genetic, and transcriptional features has revolutionized the field of medulloblastoma research over the past 5 years. Despite this, the growing body of research on miRNAs in medulloblastoma has largely focused on the clinical entity of a single disease rather than the molecular subgroups. This review begins by highlighting the role of miRNAs in development and progresses to explore their myriad of implications in cancer. Medulloblastoma is characterized by increased proliferation, inhibition of apoptosis, and maintenance of stemness programs-features that are inadvertently regulated by altered expression patterns in miRNAs. This review aims to contextualize the large body of work on miRNAs within the framework of medulloblastoma subgroups. The goal of this review is to stimulate new areas of research, including potential therapeutics, within a rapidly growing field." @default.
- W2620791330 created "2017-06-09" @default.
- W2620791330 creator A5010033363 @default.
- W2620791330 creator A5010874181 @default.
- W2620791330 creator A5016627721 @default.
- W2620791330 creator A5022310517 @default.
- W2620791330 creator A5036463140 @default.
- W2620791330 creator A5046496883 @default.
- W2620791330 creator A5047816589 @default.
- W2620791330 creator A5055594826 @default.
- W2620791330 creator A5064501346 @default.
- W2620791330 creator A5071764391 @default.
- W2620791330 creator A5087840472 @default.
- W2620791330 date "2017-06-02" @default.
- W2620791330 modified "2023-10-14" @default.
- W2620791330 title "miR miR on the wall, who’s the most malignant medulloblastoma miR of them all?" @default.
- W2620791330 cites W1493987307 @default.
- W2620791330 cites W1514842778 @default.
- W2620791330 cites W1587012969 @default.
- W2620791330 cites W1678089135 @default.
- W2620791330 cites W1727464216 @default.
- W2620791330 cites W1873830224 @default.
- W2620791330 cites W1965306643 @default.
- W2620791330 cites W1968008181 @default.
- W2620791330 cites W1972949143 @default.
- W2620791330 cites W1973696021 @default.
- W2620791330 cites W1976466295 @default.
- W2620791330 cites W1977376661 @default.
- W2620791330 cites W1980720796 @default.
- W2620791330 cites W1982717012 @default.
- W2620791330 cites W1982811429 @default.
- W2620791330 cites W1984214021 @default.
- W2620791330 cites W1985563073 @default.
- W2620791330 cites W1987205085 @default.
- W2620791330 cites W1988126723 @default.
- W2620791330 cites W1990342716 @default.
- W2620791330 cites W1993240075 @default.
- W2620791330 cites W1995338672 @default.
- W2620791330 cites W1996409634 @default.
- W2620791330 cites W1998444726 @default.
- W2620791330 cites W1999636129 @default.
- W2620791330 cites W2000418014 @default.
- W2620791330 cites W2001544973 @default.
- W2620791330 cites W2006956708 @default.
- W2620791330 cites W2010869341 @default.
- W2620791330 cites W2017308570 @default.
- W2620791330 cites W2025169368 @default.
- W2620791330 cites W2030166934 @default.
- W2620791330 cites W2033595939 @default.
- W2620791330 cites W2035658605 @default.
- W2620791330 cites W2038874091 @default.
- W2620791330 cites W2039379153 @default.
- W2620791330 cites W2042021963 @default.
- W2620791330 cites W2042593536 @default.
- W2620791330 cites W2043021563 @default.
- W2620791330 cites W2045044865 @default.
- W2620791330 cites W2046486243 @default.
- W2620791330 cites W2060862824 @default.
- W2620791330 cites W2062006415 @default.
- W2620791330 cites W2065677411 @default.
- W2620791330 cites W2073672966 @default.
- W2620791330 cites W2082080058 @default.
- W2620791330 cites W2087056964 @default.
- W2620791330 cites W2087089600 @default.
- W2620791330 cites W2089771126 @default.
- W2620791330 cites W2093746943 @default.
- W2620791330 cites W2095113583 @default.
- W2620791330 cites W2099920119 @default.
- W2620791330 cites W2100895832 @default.
- W2620791330 cites W2101847940 @default.
- W2620791330 cites W2104666653 @default.
- W2620791330 cites W2105037435 @default.
- W2620791330 cites W2105652093 @default.
- W2620791330 cites W2117293998 @default.
- W2620791330 cites W2117802141 @default.
- W2620791330 cites W2122598602 @default.
- W2620791330 cites W2123129285 @default.
- W2620791330 cites W2125472462 @default.
- W2620791330 cites W2132979600 @default.
- W2620791330 cites W2133271442 @default.
- W2620791330 cites W2133809030 @default.
- W2620791330 cites W2134816104 @default.
- W2620791330 cites W2135249598 @default.
- W2620791330 cites W2135314242 @default.
- W2620791330 cites W2135920287 @default.
- W2620791330 cites W2138746991 @default.
- W2620791330 cites W2138971681 @default.
- W2620791330 cites W2140477106 @default.
- W2620791330 cites W2141540552 @default.
- W2620791330 cites W2141738919 @default.
- W2620791330 cites W2146027678 @default.
- W2620791330 cites W2146854566 @default.
- W2620791330 cites W2148430070 @default.
- W2620791330 cites W2148929244 @default.
- W2620791330 cites W2148977460 @default.
- W2620791330 cites W2151745496 @default.
- W2620791330 cites W2154537908 @default.
- W2620791330 cites W2161272397 @default.