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- W2620791352 abstract "Advance glycated end products are a heterogeneous group of molecules formed from the non-enzymatic reaction of reducing sugars with free amino groups of proteins, lipids and nucleic acids. Advance glycation is an irreversible process, its physiological roles are to identify senescent proteins and hence there is an accumulation of advanced glycation end products. Diabetes is currently recognized as an oxidative stress disorder and hyperglycemia is a condition has an important role in the pathogenesis of diabetic complication. Diabetes has an overload of reducing sugars which accelerate advance glycated end products formation in body tissues. Interventions that can reduce advance glycated end products accumulation are also helpful in preventing the development of diabetic complications. Antioxidants can protect the formation of advanced glycated end products by blocking the free amino groups on proteins and also trap the carbonyl group. However, the efficiency of these dietary supplements against advance glycated end products in vivo is unknown. The antioxidants are now used as add on to pharmacotherapy in diabetic patients to reduce hyperglycemia and prevent advance glycated end products formation." @default.
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- W2620791352 date "2014-02-08" @default.
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- W2620791352 title "Advance Glycated End Products in Type 2 Diabetes Mellitus and Role of Dietary Supplement in their Management" @default.
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